Study on clinical effect of Yiqi Yangyin prescription imposed on gestational diabetes mellitus and perinatal outcome

Abstract

Abstract: AIM: To observe the effect of Yiqi Yangyin prescription imposed on gestational diabetes mellitus(GDM) and perinatal outcome.METHODS: 186 GDM patients were divided into experimental and control groups randomly. The patients of experimental group were given the Chinese medicine of Yiqi Yangyin prescription and medical nutrition therapy.The patients of control group were given medical nutrition therapy only.Biochemical tests including fasting blood glucose, postprandial blood glucose,glycosylated hemoglobin and fasting insulin as well as indices of insulin resistance (HOMA-IR) were carried out for all patients before and after the treatment. Maternal and fetal outcomes were analyzed in two groups after delibery.RESULTS: There was no significant difference between the two groups before treatment(P>0.05). The 2-hour postprandial blood glucose,fasting insulin,glycosylated hemoglobin and HOMA-IR of two groups were all improved to different degrees(P<0.05), and those of the experimental group improved more significantly(P<0.05). The rate of cesarean section,premature rupture of membrane,preeclampsia,postpartum hemorrhage,neonatal sphyxia,fetal distress, fetal macrosomia in experimental group were significantly lower than those in control group(P<0.05).CONCLUSION: The Yiqi Yangyin prescription has a favourable curative effect on glucose control and insulin resistance as well as maternal and fetal outcomes.

Key words: Gestational diabetes mellitus, Yiqi Yangyin prescription, Blood glucose, Maternal and fetal outcomes

CLC Number:

R587.1

LIU Yi, CHEN Jie, CHI Li-fang. Study on clinical effect of Yiqi Yangyin prescription imposed on gestational diabetes mellitus and perinatal outcome[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 408-412.

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