Abstract: AIM: To observe the effects and safety of combining with Pinaverium bromide and Zanglian pill on patients with irritable bowei syndrome (IBS).METHODS: 200 IBS patients were randomly divided into two groups(n=100). 100 patients were selected as study group, who were treated by Zanglian pill combined with Pinaverium bromide while the other 100 patients as control group were treated by Pinaverium bromide only.RESULTS: After treatment, all patients showed significant improvements of clinical symptom (P<0.05).The effective power was 97% in study group, was better than that in control group(80%,P<0.05). The two groups were not found significant adverse drug reactions.CONCLUSION: Zanglian pill combined with Pinaverium bromide have more clinic effects for treating IBS.

Key words: Pinaverium bromide, Zanglian pill, Irritable bowel syndrome, Clinical effect