Abstract: AIM: To observe the effect and clinical significance of Danshen injection on human chorionic gonadotropin of abnormal systolic/diastolic ratio in the third trimester.METHODS: 100 third trimester women with abnormal systolic/diastolic ratio were randomly divided into the control group (n=50) and treatment group (n=50). Control group was given 5% glucose 500 mL+vitamin C 2.0 g. Treatment group was given the same medication as the control group and 5% glucose 500 m+Danshen injection 10 mL, seven days one period of treatment. Umbilical artery PI,RI,S/D and concentration of β-hCG in maternal serum were detected before and after the medication.RESULTS: PI,RI,S/D and β-hCG level in the treatment group were higher than that of the control group(P<0.05); PI,RI,S/D and β-hCG level of the two groups before treatment were higher than that of the two groups after treatment (P<0.01); β-hCG level was positively correlated with S/D(r=0.485,0.458,P<0.01).CONCLUSION: Danshen injection treatment abnormal systolic/diastolic ratio in the third trimester for its excellent curative effect, with serum β-hCG level measurement can increase the detection rate of abnormal placental function.

Key words: Danshen injection, Human chorionic gonadotropin, Third trimester, Abnormal systolic/diastolic ratio