Abstract: AIM: To explore the impact of the Escherichia coli resistant line after colorectal cancer patients with preoperative oral intestinal antibiotics for bowel preparation. METHODS: 100 cases with colorectal cancer were randomly divided into observation group and control group. The observation group (50 cases) was treated with oral intestinal antibiotics one day. The control group (50 cases) was treated with intestinal antibiotics three days. The Colonic mucosa attachments taken from all patients during operation,were bacterial cultured and sensitive tests. The results of the two groups were compared.RESULTS: The positive rate of colonic mucosa attachments Escherichia coli culture of one day group and three days group were 46% and 40%,respectively. The drug resistance of three days group of Escherichia coli was increased than those of one day group of amikacin, gentamicin, ciprofloxacin and levofloxacin (P<0.05).Both groups were all resistant to ampicillin, while ertapenem, imipenem, and Paila West/tazobactam were all sensitive.CONCLUSION: Using intestinal antibiotics for colorectal cancer patients with preoperative bowel preparation, three days program increased resistance for Escherichia coli on the part of the drug. Preoperative bowel preparation should minimize taking antibiotics.

Key words: Colorectal cancer, Antibiotic, Bowel preparation, Escherichia coli, Drug resistance