Immune mechanism of transfusion-related acute lung injury

Abstract

Abstract: TRALI is one type of new-onset acute lung injury that happens within 6 h of initiation of any blood transfusion. It is one of the most common causes of transfusion-related morbidity and mortality. Both basic and clinical researches have demonstrated that immune priming is a fundamental step for lung injury. Antigen-antibody reactions trigger a series of events that lead to TRALI, which mainly relate to HLA and HNA antibodies of blood products. The prevetion is very important for TRALI and research on mechanism of TRALI will be still a key point.

Key words: Transfusion-related acute lung injury, Immunology, Human lencocyte antigens, Human neutrophit antigen

CLC Number:

R563

LI Rui, HUANG Yu-guang. Immune mechanism of transfusion-related acute lung injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(5): 575-579.

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