Application of antioxidant stress in the therapy of hypertension

Abstract

Abstract: Hypertension is one of the most common cardiovascular diseases. In recent years, a large number of studies have shown that oxidative stress is the main reason for the vascular injury, which may be an important pathological mechanism that can lead to hypertension. The increasing level of reactive oxygen species (ROS), leading to increased oxidative stress induced an increase in blood pressure. Hypertension will further promote the generation of ROS, leading to tissue oxidative injury. Recently, the anti-oxidative stress therapy research attracted the attention of many researchers at home and abroad. The clinical application of oxidative stress in the treatment of hypertension have achieved certain results. The aim of the present review is to describe the contribution of oxidative stress to hypertension and anti-oxidative stress pharmacotherapy.

Key words: Oxidative stress , ROS , Hypertension, Therapy

CLC Number:

R544

LIU Xiao-li, YUAN Hong, HUANG Zhi-jun, LI Ying. Application of antioxidant stress in the therapy of hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(5): 580-585.

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