Abstract: AIM: To evaluate the effect of Re-Du-Ning on airway oxidative stress and systemic inflammation of acute exacerbation of chronic obstructive pulmonary disease (COPD) with influenza virus infection.METHODS: 320 of COPD out-patients suspected with respiratory virus were enrolled from respiratory clinic successively. Respiratory syndrome, sputum and blood samples had been collected in the first morning after enrolled. After influenza virus in sputum was detected by RT-PCR, the patients with influenza virus were divided into 2 groups: Re-Du-Ning group, who received the treatment of Re-Du-Ning and control group, who received the treatment without Re-Du-Ning and other antioxidants.RESULTS: After treatment, BDI not MRC of Re-Du-Ning group was higher than control group with significant difference (P<0.05). MDA was lower in treatment group than in control group, so as IL-8, and the activity of SOD in treatment group was higher than that in control group (P<0.05).CONCLUSION: Re-Du-Ning improves the respiratory syndrome and systemic inflammation of chronic obstructive pulmonary disease with influenza virus infection via regulating of the imbalance of oxidative stress.

Key words: Chronic obstructive pulmonary disease, Influenza virus, Oxidative stress, Re-Du-Ning