Abstract: AIM: To investigate the effect of intensive dose atorvastatin in the use of iopamidol,a kind of low osmolar and non-ionic contrast agent,on renal function of patientsMETHODS: 200 patients who undergoing CAG and PCI were randomized to intensive dose atorvastatin group (80 mg 24 h before PCI,with a further 40 mg 2 h pre-procedure,n=100)or routine dose atorvastatin group (20 mg/d,n=100).All patients received intravenous saline hydration.And those who undergoing percutaneous PCI were divided into two groups according to different dosages of contrast agent :≤120 mL group and >120 mL group.The levels of Scr,BUN,and hsCRP were determined for the evidence of tubular or glomerular damage befour and after receiving diagnostic and therapeutic coronary intervention.Ccr was calculated according to Cockcroft-Gault formula.RESULTS: Compared with before operation,the values of Scr and BUN in two groups of patients were obviously higher after operation;but the value of Ccr was lower (P<0.05);the value of hsCRP was increased in routine dose atorvastatin group(P<0.05),the value of hsCRP was no change in intensive dose atorvastatin group(P>0.05).There was no significant difference in the values of renal function between ≤120 mL group and >120 mL group in intensive dose atorvastatin group.Compared with the >120 mL group,the values of the Scr,BUN,hsCRP were increased(P<0.05),the value of Ccr was decreased(P<0.05).The renal function had obvious diffenence in routine dose atorvastatin group between ≤120 mL group and >120 mL group. There were 12 patients with contrast-induced nephropathy (CIN)in routine dose atorvastatin group and the incidence of CIN was 12%;there were 8 patients with contrast-induced nephropathy (CIN)in>120 mL group,and the incidence of CIN was 14％.CONCLUSION: The use of intensive dose atorvastatin before angiography can reduce the effect of renal function induced by high dose of contrast agent and prevent the incidence of CIN.

Key words: Atorvastatin, Contrast-induced nephropathy, Non-ionic low permeability contrast agent