Abstract: AIM: To evaluate the therapeutic effect of ¹³¹I on patients with Graves disease, and analyze the influence factors of curative effect and the hypothyroidism occurrence.METHODS: The 398 patients had been retrospectively studied with definite diagnosis of Graves' disease within 2011 to 2012 after ¹³¹I treatment.RESULTS: Total curative rate was 46.7%, and the total effective rate was 86.7%. For the first time of treatment, the curative rate was 48.6%, and the effective rate was 87.3%. In most of the patients, the serum FT4 and FT3 were decreased in one to three months post ¹³¹I treatment. After statistical analyzing, 24 h ¹³¹I uptake rates, thyroid weight, dosage of ¹³¹I ,the number of treatment, were negative correlation with the curative rate, and with liver injury was also a impairing factors of therapy. Furthermore, in the numerous factors mentioned above, only 24 h ¹³¹I uptake rate has relationship with hypothyroidism occurrence in Single factor analysis way, which show as the lower iodine uptake rate with the higher incidence of hypothyroidism (χ²=7.487,P=0.02367);Multiple logistic regression analysis suggested that the gender, thyroid weight,the mumbers of treatment were significantly associated with the incidence of hypothyroidism.CONCLUSION: The curative effect of ¹³¹I therapy on Graves's disease was acceptable, and it can be used as the first choice of therapy for Graves's disease. However, individualized dosage should be used for the patients, because of the complex influence factors of therapeutic effects.

Key words: Graves disease, Iodine 131, Therapy, Hypothyroidism