Abstract: AIM: To detect the level of serum γ-glutamyltransferase and evaluate it's relationship with left ventricular diastolic function in type 2 diabetes mellitus.METHODS: A cross-sectional study of 46 type 2 diabetes patients with or without left ventricular diastolic dysfunction were divided into two groups.The levels of serum γ-glutamyltransferase,TC and TG were analyzed.Left ventricular diastolic function was assessed by pulsed Doppler tissue imaging and was determined by ratio E wave/A wave.RESULTS: There were no significant difference about sex, BMI,systolic blood pressure, diastolic blood pressure, HbA1c,total cholesterol and triglyceride in two groups of patients(P＞0.05). Compared with the left ventricular diastolic function group,the level of serum γ-glutamyltransferase was obviously higher in left ventricular diastolic dysfunction group,there was significant difference(P＜0.01). Negative correlations were found between γ-glutamyltransferase and E/A in left ventricular diastolic dysfunction group(r=-0.681,P＜0.000).CONCLUSION: The level of serum γ-glutamyltransferase was increased in type 2 diabetic patients with left ventricular diastolic dysfunction.The level of serum γ-glutamyltransferase might be an marker of diastolic dysfunction in type 2 diabetes patients.

Key words: γ-glutamyltransferase, Diabetes mellitus, Type 2, Left ventricular diastolic function