Effects of Huanglian-Jie-Du-Tang on learning and memory in aging mice

Abstract

Abstract: AIM: To investigate the potential anti-aging effect of Huanglian-Jie-Du-Tang (HJDT) and explore the mechanism in mice.METHODS: The ICR mice were divided into normal control group, aging model group and HJDT treated group (1, 2, 4, and 8 g/kg). Aging mice were induced by subcutaneously injection with D-galactose. The spontaneous activity and the learning and memory ability were evaluated by a locomotor test and step down test. The SOD activity and the MDA level were measured by xanthine oxidase method and thiobarbituric acid method.RESULTS: Compared with the normal control group, the learning and memory ability and the MDA level decreased and the SOD activity increased in aging mice, which were markedly reversed by HJDT (2 and 4 g/kg). But there was no significant effect of HJDT (1 and 8 g/kg).CONCLUSION: HJDT ameliorates learning and memory impairment in D-galactose-induced aging mice through its potent antioxidant activities.

Key words: Huanglian-Jie-Du-Tang(HJDT), D-galactose, aging, anti-oxidant

CLC Number:

R965.2

YE Qiao-hong, CHEN Shan-shan, LI Sheng-jian, YE Yi-lu, ZHANG Qi, YU Yue-ping, WANG Jue. Effects of Huanglian-Jie-Du-Tang on learning and memory in aging mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 162-165.

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