Studies on absorption kinetics of gambogenic acid in rat's intestines

Abstract

Abstract: AIM: To investigate the absorption kinetic characteristics of Gambogenic acid at different intestine segments in rats and provide reliable biopharmaceutics basis of novel drug delivery systems of Gambogenic acid.METHODS: The rat intestinal absorption model was established to investigate the influence of different concentrations (3.0,10.0,30 μg/mL) and intestine segments on the intestinal absorption of GNA. Gambogenic acid concentration was measured by the RP-HPLC.RESULTS: Within the range from 3.0-30.0 μg/mL, the absorption rate and the quality concentration of Gambogenic acid had a linear relation. The permeability coefficient of Gambogenic acid at colon, ileum, jejunum, duodenum were(0.03944±0.00158), (0.04012±0.00103), (0.04104±0.00124) ,(0.08620±0.00272) h^-1,respectively.CONCLUSION: The absorption of Gambogenic acid conforms to passive diffusion mechanism and first-order kinetics. Gambogenic acid could be absorbed in whole intestinal segments, so it is feasible for Gambogenic acid to be designed as a controlled-release formulation.

Key words: Gambogenic acid, rat, intestinal absorption kinetics, HPLC

CLC Number:

CHEN Jin-pei, WANG Shan-shan, WANG Dian-lei, YANG Li-li, WANG Chen-yin, TAO Xiu-hua, CAO Yin, WANG Shu-jun, CHEN Ya-jun. Studies on absorption kinetics of gambogenic acid in rat's intestines[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(2): 166-170.

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