Advancement on pathogenesis of chemotherapy induced intestinal mucositis and its drug intervention: a review

Abstract

Abstract: Intestinal mucositis is a common adverse reaction during chemotherapy, which was with high incidence, toxic, serious impact on cancer treatment and quality of life. Studies show that the pathogenesis of intestinal mucositis induced by chemotherapy is complex, thus the current drug intervention strategies were more, but the curative effect is not exact. In this paper, we reviewed the etiology of intestinal mucosal inflammation induced by chemotherapy and its possible mechanism, and summarized the possible mitigation way to alleviate the chemotherapy induced side effects. From this paper, we could provide reference for the development of rational treatment of this disease and related drugs.

Key words: chemotherapy, intestinal mucositis, treatment strategies

CLC Number:

R574

GUO Jin-rui, ZHAN Zhen, KANG An, WANG Xiao-long. Advancement on pathogenesis of chemotherapy induced intestinal mucositis and its drug intervention: a review[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(5): 573-578.

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