Recent progresses on antibody-targeted conjugates of antitumor antibiotics

Abstract

Abstract: Recent studies have reported that some antibiotics such as calicheamicin and lidamycin display potent cytotoxicity respectively to variousmolecular targets, so they can be used as potent “warhead” agent to constitute antibody-targeted conjugates including immunoconjugates and fusion proteins. Antibody-targeted drugs exert a powerful antitumor potency because of its specific distribution and function in vivo. This paper mainly reviews on the construction and effect characteristics of antibody-targeted conjugates of antitumor antibiotics and provide a preliminary outlook for its future research direction.

Key words: antitumor antibiotics, antibody-targeted conjugates, immunoconjugate, energized fusion proteins

CLC Number:

R963

SHANG Li-na, HONG Ming-yue. Recent progresses on antibody-targeted conjugates of antitumor antibiotics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(9): 1075-1080.

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