Progress on effects of pharmacogenetics of inosine triphosphate pyrophosphatase on improving the individualized thiopurine therapy

Abstract

Abstract: Thiopurines, one kind of immunosuppressive agents,represent an effective and widely prescribed therapy in clinical application. However, the narrow therapeutic window and pharmacokinetic variability has been always a difficult problem to the clinical use of these drugs. Although the gene polymorphisms of thiopurine methyltransferase (TPMT) are considered to be the main genetic factors that affect pharmacokinetics of thiopurine drugs, but the conclusions of these studies are not consistent. However, some recent studies have focused on the genetic polymorphisms of inosine triphosphate pyrophosphatase (ITPA). Therefore, this review summarizes the recent research progress on influence of the genetic polymorphisms of ITPA on efficacy and toxicity of thiopurines, so as to provide guidance for individualized treatment in the clinical practice.

Key words: thiopurines, genetic polymorphism, inosine triphosphate pyrophosphatase, individual variation

CLC Number:

R968

FENG Jing, WU Yue, RONG Pei-pei, SHEN Bing-zheng, ZHOU Ding-shan, SHI Cai, SONG Jin-chun. Progress on effects of pharmacogenetics of inosine triphosphate pyrophosphatase on improving the individualized thiopurine therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1435-1440.

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