Linezolid pharmacokinetics/pharmacodynamics and the development of dosage regimen design optimization

Abstract

Abstract: To provide reference for clinical reasonable application by introducing linezolid pharmacokinetics and pharmacodynamics characteristics in different diseases. The data from CNKI,PUBMED were analyzed. On the basis of PK/PD parameters, the dosage regimen was optimized, which could better improve the curative effect of antimicrobial drugs, and reduce the incidence of adverse reactions, drug resistance and the patients' economic burden. Linezolid had strong antibacterial effect against gram-positive bacteria. It is meaningful to study on the optimum dosage regimen and promote the rational drug use due to the different pathological physiological factors instead of PK/PD characteristics.

Key words: linezolid, PK/PD, disease, dosage regimen

CLC Number:

R969.1

JIN Yan-jie, ZHANG Jing, LU Ke-peng, LIU Qian, LIN Li-min, SONG Hong-tao. Linezolid pharmacokinetics/pharmacodynamics and the development of dosage regimen design optimization[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1429-1434.

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