Abstract: Platelet aggregation inhibitors therapy, such as aspirin or clopidegrel, should be stopped for 5-7 d before no-cardiac surgery in the Clinical Guide to the Chinese Pharmacopoeia 2010 and Chinese National Formulary for Children (CNFC). Platelet regenerating time in blood, being 7-14 d, is longer than the time stopping therapy for 5-7 d. It would be blood preoperative for no-cardiac surgery because of lots of platelets without coagulation function existing in blood. The precaution of aspirin and clopidegrel in the Clinical Guide to the Chinese Pharmacopoeia 2010 and Chinese National Formulary(CNF) should be improved. To prevent bleeding in selective operations, no administration of aspirin and clopidegrel should be set at 10-14 days before the operation. If bleeding in or after the operation, fresh platelet should be transfused to stop the bleeding. The precaution of ticlopidine in the Chinese National Formulary 2010 and Chinese National Formulary for Children is not correct because no administrating ticlopidine 10-24 d before the operation should be corrected as 10-14 days before the operation.

Key words: aspirin, clopidegrel, ticlopidine, platelet, CNF