Abstract: AIM: To investigage the effects of Qin bai fu fang tang shang gao (QBFFTSG) on burn wound healing in rats.METHODS: The model of deep grade Ⅱskin burn wounds in rats was established. A total of 130 model rats were divided into 5 groups as follows: high, middle and low concentration of QBFFTSG treatment group, non - treatment group, Shi run shao shang gao (SRSSG) treatment group was used as positive control. Scab area, healing time of burn wound and wound tissues were taken at different times after wound induction for analysis and assessment of each parameter. Histopathology of wound tissues and microvascular density (MVD) with factor Ⅷ immunohistochemistry staining were measured. The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were determined.RESULTS: QBFFTSG (0.4, 0.2, 0.1 g extract/g crude drug) could decrease the scab area and healing time, improve the histopathological changes of burn wound, increase the MVD density, decrease the elevated serum MDA content and increase the serum SOD level in rats at varying degrees during wound healing.CONCLUSION: QBFFTSG produces an enhanced protective effect on wound tissues of rats which could obviously promote the wound healing and improve the histopathological changes of wounds. The mechanism of action of QBFFTSG may be attributed to wound angiogenesis and anti-lipid peroxidation in rats.

Key words: QBFFTSG, burn, microvascular density, lipid peroxidation, histopathology