Abstract:

AIM: To study the function of combined use of curcuma longa L.extracts and atorvastatin calcium on lipid-lowering of hyperlipidemia mice.  METHODS: Hyperlipidemia mice models were established successfully by feeding with high-fat diet, and were divided into 4 groups: hyperlipidemia model group, curcuma longa L. extracts group, atorvastatin group, combination group of curcuma longa L. extracts and atorvastatin. The mice were fed with high-fat diet and administrated for 5 weeks with different doses of curcuma longa L. extracts and atorvastatin. Weight, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of mice were detected.RESULTS:Compared with hyperlipidemia model group, the TC, TG and LDL-C of the combination group of curcuma longa L. extracts and atorvastatin were significantly decreased (P<0.01) by 44.10%, 38.30% and 37.24%, respectively, while HDL-C was significantly increased (P<0.05). CONCLUSION: The combined use of curcuma longa L. extracts and atorvastatin can efficiently reduce blood lipid, and exhibits better effect in treating hyperlipidemia than single use.

Key words: hyperlipidemia, mice, curcuma longa L. extracts, atorvastatin