关键词: 单胎, 双胎, 新生儿疾病筛查, 先天性肾上腺皮质功能增生症, 17-羟孕酮

Abstract: Objective To analyse congenital adrenal hyperplasia (CAH) screening results of singletons and twins newborns in Guangxi,and discover the relationship between fetus number and 17-hydroxyprogesterone(17-OHP) level. Methods Newborns born from January 2012 to June 2015 in Guangxi were screened for CAH.Time-resolved fluoroimmunoassay was used to measure blood 17-OHP level.χ² test was used to compare 17-OHP level of singletons and twins. Results In 378 252 newborns,twins were 9 464,suspected positive rate of singletons and twins was 2.85% and 0.38% respectively.Gestation age,birth weight,suspected positive rate and prevalence of singletons and twins had significant differences (P<0.01). Conclusions Positive rate and prevalence of CAH of twins are higher than singletons.One of twin is suspected positive,the other should be recalled to prevent missed diagnosis.

Key words: singletons, twins, newborn screening, congenital adrenal hyperplasia, 17-hydroxyprogesterone