儿童肥胖相关性哮喘治疗策略的研究进展

doi:10.11852/zgetbjzz2018-1737

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (12): 1317-1319.DOI: 10.11852/zgetbjzz2018-1737

儿童肥胖相关性哮喘治疗策略的研究进展

孙柳钰 (综述), 曲书强 (审校)

哈尔滨医科大学附属第二医院儿内科,黑龙江哈尔滨 150086

收稿日期:2019-01-12 修回日期:2019-02-23 发布日期:2019-12-10 出版日期:2019-12-10
通讯作者: 曲书强,E-mail:qsq1962@aliyun.com
作者简介:孙柳钰(1992-),女,黑龙江人,硕士研究生,主要研究方向为小儿呼吸系统疾病

Research progress on the treatment strategy of obesity related asthma in children

SUN Liu-yu,QU Shu-qiang

Department of Pediatrics,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China

Received:2019-01-12 Revised:2019-02-23 Online:2019-12-10 Published:2019-12-10

摘要/Abstract

摘要： 肥胖和哮喘为全球范围内的两个重要儿科疾病,随着我国经济的发展,这两个疾病在近些年发病率呈现了爆发式增长。在临床经验的基础上,通过对相关文献的回顾,证实了肥胖相关性哮喘这一表型的存在。其特点是难以控制,症状较重,对吸入糖皮质激素不敏感,发作频繁,生活质量低于其他表型。当前大多数研究只强调了对于哮喘的治疗,而忽略了肥胖对其的影响。针对肥胖相关性哮喘患儿来说,除了哮喘的治疗,也同时应该减轻体重,以改善肥胖对于疾病产生的影响。本综述的目的是探讨儿童肥胖相关性哮喘可行的治疗策略,以便更好地治疗。

关键词: 肥胖, 哮喘, 体重指数, 减重治疗

Abstract: Obesity and asthma are two important pediatric diseases all over the world. With the development of economy,the incidence of these two diseases has increased dramatically in recent years. Based on the clinical experience,the phenotype of obesity related asthma is confirmed by reviewing the relevant study. The characteristics of obesity related asthma are difficult to control,severe symptoms,insensitive to inhaled glucocorticoid,frequent attacks,lower quality of life than other phenotypes. Most current studies focus on the treatment of asthma,ignoring the effects of obesity. In addition to asthma treatment,children with obesity related asthma should also lose weight to alleviate the impact of obesity on asthma. This review is aimed to explore feasible treatment strategies for obesity-associated asthma in children.

Key words: obesity, asthma, body mass indes, weight loss treatment

中图分类号:

:R725

孙柳钰, 曲书强. 儿童肥胖相关性哮喘治疗策略的研究进展[J]. 中国儿童保健杂志, 2019, 27(12): 1317-1319.

SUN Liu-yu,QU Shu-qiang. Research progress on the treatment strategy of obesity related asthma in children[J]. journal1, 2019, 27(12): 1317-1319.

参考文献

[1] 刘传合,洪建国,尚云晓.中国城市儿童哮喘患病率年对比研究[J].中国实用儿科杂志,2015,30(8):596-600.
[2] 于冬梅,琚腊红,赵丽云.中国0～5岁儿童超重肥胖分布特征[J].中华流行病学杂志,2018,39(6):710-714.
[3] 房红芸,翟屹,赵丽云.中国6～17岁儿童青少年超重肥胖流行特征[J].中华流行病学杂志,2018,39(6):724-727.
[4] Forno E,Celedón JC.The effect of obesity,weight gain,and weight loss on asthma inception and control[J].Curr Opin Allergy Clin Immunol,2017,17(2):123-130.
[5] Forno E,Weiner DJ,Mullen J,et al.Obesity and airway dysanapsis in children with and without asthma[J].Am J Respir Crit Care Med,2017,195(3):314-323.
[6] Rastogi D,Holguin F.Metabolic dysregulation,systemic inflammation,and pediatric obesity-related asthma[J].Ann Am Thorac Soc,2017,14(Suppl 5):363-367.
[7] 中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南2016年版[J].中华儿科杂志,2016,54(3):167-181.
[8] Mcgarry ME,Castellanos E,Thakur N,et al.Obesity and bro nchodilator response in black and hispanic children and adolescents with asthma[J].Chest,2015,147(6):1591-1598.
[9] Peters-Golden M,Swern A,Bird SS,et al.Influence of body mass index on the response to asthma controller agents[J].Eur Respir J,2006,27(3):495-503.
[10] Chen Z,Salam MT,Alderete TL,et al.Effects of childhood asthma on the development of obesity among school-aged children[J].Am J Respir Crit Care Med,2017,195(9):1181-1188.
[11] Vijayakanthi N,Greally JM,Rastogi D.Pediatric obesity-related asthma:the role of metabolic dysregulation[J].Pediatrics,2016,137(5):e20150812.
[12] Willeboordse M,van de Kant KDG,Tan FE,et al.A multifactorial weight reduction programme for children with overweight and asthma:a randomized controlled trial[J].PLoS One,2016,11(6):e0157158.
[13] Leinaar E,Alamian A,Wang L.A systematic review of the relationship between asthma,overweight,and the effects of physical activity in youth[J].Ann Epidemiol,2016,26(7):504-510.
[14] Holderness H,Chin N,Ossip DJ,et al.Physical activity,restrictions in activity,and body mass index among urban children with persistent asthma[J].Ann Allergy Asthma Immunol,2017,118(4):433-438.
[15] Willeboordse M,van de Kant KD,van der Velden CA,et al.Associations between asthma,overweight and physical activity in children:a cross-sectional study[J].BMC Public Health,2016,16(1):919.
[16] Diaz J,Farzan S.Clinical implications of the obese-asthma ph enotypes[J].Immunol Allergy Clin North Am,2014,34(4):739-751.
[17] Jensen ME,Gibson PG,Collins CE,et al.Diet-induced wei ght loss in obese children with asthma:a randomized controlled trial[J].Clin Exp Allergy,2013,43(7):775-784.
[18] Nagel G,Weinmayr G,Kleiner A,et al.Effect of diet on asthma and allergic sensitisation in the international Study on Allergies and Asthma in Childhood(ISAAC) Phase Two[J].Thorax,2010,65(6):516-522.
[19] Lang JE,Mougey EB,Allayee H,et al.Nutrigenetic respon se to omega-3 fatty acids in obese asthmatics(NOOA):rationale and methods[J].Contemp Clin Trials,2013,34(2):326-335.
[20] Mickleborough TD,Murray RL,Ionescu AA,et al.Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes[J].Am J Respir Crit Care Med,2003,168(10):1181-1189.
[21] Mickleborough TD,Lindley MR,Ionescu AA,et al.Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma[J].Chest,2006,129(1):39-49.
[22] Vo P,Bair-merritt M,Camargo CA.The potential role of vitamin D in the link between obesity and asthma severitycontrol in children[J].Expert Rev Respir Med,2015,9(3):309-325.
[23] Pojsupap S,Iliriani K,Sampaio TZ,et al.Efficacy of high-dose vitamin D in pediatric asthma:a systematic review and meta-analysis[J].J Asthma,2015,52(4):382-390.
[24] Tachimoto H,Mezawa H,Segawa T,et al.Improved control of childhood asthma with low-dose,short-term vitamin D supplementation:a randomized,double-blind,placebo-controlled trial[J].Allergy,2016,71(7):1001-1009.
[25] Lang JE.Obesity and asthma in children:current and future therapeutic options[J].Paediatr,2014,16(3):179-188.
[26] Styne DM,Arslanian SA,Connor EL,et al.Response to letter pediatric obesity-assessment,treatment,and prevention an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2017,102(6):2123-2124.

儿童肥胖相关性哮喘治疗策略的研究进展

Research progress on the treatment strategy of obesity related asthma in children

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	刘浩东, 李成, 赵敏, 席波. 儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 707-712.
[2]	霍言言, 刘钟泠, 马玲, 吴丹, 汪秀莲, 仇晓艳, 窦家莹, 任玉倩, 李亦诚, 洪霞, 陈津津. 真实世界2岁以下儿童不同体型匀称度现况及风险因素[J]. 中国儿童保健杂志, 2023, 31(7): 718-723.
[3]	李茗竹, 王静, 谢多双. 小于胎龄儿过快追赶生长与儿童期肥胖关系的研究[J]. 中国儿童保健杂志, 2023, 31(7): 751-755.
[4]	张容, 吴襄仪, 朱一民, 朱文丽, 《儿童肥胖预防与控制指南》修订委员会. 就餐地点与儿童肥胖的定性循证研究[J]. 中国儿童保健杂志, 2023, 31(7): 775-780.
[5]	王小丽, 董青, 孙丰燕, 陈丽萍, 姚国, 史宝海. 泰安地区2021年小学生超重和肥胖的流行病学调查[J]. 中国儿童保健杂志, 2023, 31(7): 799-803.
[6]	曹亚船, 豆吉娟, 马亚萍, 任金冬, 陈新颜. 肥胖儿童脂质代谢与左心室肥厚及左心室重构的相关性[J]. 中国儿童保健杂志, 2023, 31(7): 809-812.
[7]	马冰洁, 卢少敏, 邢艳菲, 梁晶晶. 超重肥胖儿童智力水平及执行功能的表现特征[J]. 中国儿童保健杂志, 2023, 31(6): 601-605.
[8]	吴淑堃, 孙晓宇, 梁瑞华, 左群. 体质量指数对视屏行为与学龄儿童运动乐趣关系的中介作用[J]. 中国儿童保健杂志, 2023, 31(5): 470-474.
[9]	牛婉侠, 梁爽, 王一彪. 儿童肥胖相关心肌病的分子机制[J]. 中国儿童保健杂志, 2023, 31(5): 507-511.
[10]	姚丽娟, 胡晓, 姜伟伟. 2015—2022年龙口市中小学生超重肥胖变化趋势的8年追踪研究[J]. 中国儿童保健杂志, 2023, 31(5): 546-550.
[11]	廖晶, 朱琳. 人体测量学指标预测13~16岁肥胖青少年血脂异常风险的列线图模型[J]. 中国儿童保健杂志, 2023, 31(4): 379-384.
[12]	刘维韦, 娄海琴, 付路, 代倩倩. 学龄前超重肥胖儿童生存质量现状及影响因素分析[J]. 中国儿童保健杂志, 2023, 31(4): 385-389.
[13]	刘芮卓, 陈立. 儿童注意缺陷多动障碍与肥胖的相关性研究[J]. 中国儿童保健杂志, 2023, 31(4): 412-415.
[14]	蔡文萍, 郭妮娅. 乌鲁木齐市中小学生膳食模式与超重肥胖的相关性研究[J]. 中国儿童保健杂志, 2023, 31(4): 433-437.
[15]	买国华. 学龄期支气管哮喘患儿自我管理行为调查及影响因素[J]. 中国儿童保健杂志, 2023, 31(4): 446-450.