维生素D在孤独症谱系障碍中作用的研究进展

doi:10.11852/zgetbjzz2019-1760

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (10): 1122-1125.DOI: 10.11852/zgetbjzz2019-1760

所属专题：孤独症谱系障碍

维生素D在孤独症谱系障碍中作用的研究进展

夏阳综述, 仰曙芬审校

哈尔滨医科大学附属第二医院儿科,黑龙江哈尔滨 150081

收稿日期:2019-11-18 修回日期:2020-03-02 发布日期:2020-10-10 出版日期:2020-10-10
通讯作者: 仰曙芬,E-mail:yangshufen513@126.com
作者简介:夏阳(1993-),女,黑龙江人,硕士研究生,主要研究方向为儿童保健。

Research advances on the role of vitamin D in autism spectrum disorders

XIA Yang, YANG Shu-fen

Department of Pediatrics,the Second Affiliated Hospital ofHarbin Medical University,Harbin,Heilongjiang 150081,China

Received:2019-11-18 Revised:2020-03-02 Online:2020-10-10 Published:2020-10-10
Contact: YANG Shu-fen,E-mail:yangshufen513@126.com

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是影响儿童健康的严重公共问题之一,以社交沟通障碍、兴趣或活动范围狭窄以及重复刻板行为为特征。近年来越来越多的研究显示,ASD患儿维生素D(VitD)水平明显低于同龄健康儿童,VitD缺乏可能与ASD的发病机制相关。本文就VitD与ASD的相关研究进行综述。

关键词: 孤独症谱系障碍, 维生素D, 神经发育

Abstract: Autism spectrum disorders (ASD) is one of the serious public problems affecting children′s health,characterized by social communication disorder,narrow interest or activity range and repetitive stereotyped behavior.In recent years,increasing studies have shown that the level of vitamin D (Vit D) in ASD children is significantly lower than that of healthy children with the same age,and vitamin D deficiency may be related to the pathogenesis of ASD.This paper reviews the research progress on vitamin D and ASD.

Key words: autism spectrum disorders, vitamin D, neurodevelopment

中图分类号:

R749.94

夏阳, 仰曙芬. 维生素D在孤独症谱系障碍中作用的研究进展[J]. 中国儿童保健杂志, 2020, 28(10): 1122-1125.

XIA Yang, YANG Shu-fen. Research advances on the role of vitamin D in autism spectrum disorders[J]. journal1, 2020, 28(10): 1122-1125.

参考文献

[1] Baio J,Wiggins L,Christensen DL,et al.Prevalence of autism spectrum disorder among children aged 8 years-Autism and Developmental Disabilities Monitoring Network,11 Sites,United States[J].MMWR Surveill Summ,2018,67(6):1-23.
[2] 戴琼,徐海青,汪鸿,等.2000-2016年中国儿童孤独症谱系障碍患病率Meta分析[J].中国儿童保健杂志,2017,25(12):1243-1246.
[3] Mácová L,Biciková M,OstatniKová D,et al.Vitamin D neurosteroids and autism[J].Physiol Res,2017,66(Suppl 3):333-340.
[4] Yates NJ,Tesic D,Feindel KW,et al.Vitamin D is crucial for maternal care and offspring social behaviour in rats[J].Endocr,2018,237(2):73-85.
[5] Hawes JE,Tseic D,Whitehouse AJ.et al.Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J].Behav Brain Res,2015,286:192-200.
[6] Cannell JJ.Vitamin D and autism,what′s new?[J].Rev Endocr Metab Disord,2017,18:183-193.
[7] Sharmi B,Bushra K,Charan J,et al.Fok-I,Bsm-I,and Taq-I variants of vitamin D receptor polymorphism in the development of autism spectrum disorder:a literature review[J].Cureus,2018,10(8):e3228.
[8] Kałuzna-Czaplińska J,Jóźwik-Pruska J,Chirumbolo S,et al.Tryptophan status in autism spectrum disorder and the influence of supplementation on its level[J].Metab Brain Dis,2017,32:1585-1593.
[9] 吴光驰.维生素D缺乏离我们有多远[J].中国妇幼卫生杂志,2014,5(5):72-76.
[10] Wang T,Shan L,Du L,et al.Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder:a systematic review and meta-analysis[J].Eur Child Adolesc Psychiatry,2016,25:341-350.
[11] Arastoo AA,Khojastehkia H,Rahimi Z,et al.Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder,Italian[J].Pediatr,2018,44:150.
[12] Guo M,Zhu J,Yang T,et al.Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders[J].Nutr Neurosci,2019,22(9):637-647.
[13] Wu DM,Wen X,Han XR,et al.Relationship between neonatal vitamin D at birth and risk of autism spectrum disorders:the NBSIB study[J].Bone Miner Rese,2017,33(3):458-466.
[14] García-Serna AM,Morales E.Neurodevelopmental effects of prenatal vitamin D in humans:systematic review and meta-analysis[J].Mol Psychiatr,2019.doi:/10.1038/s41380-019-0357-9.
[15] Vinkhuyzen AAE,Eyles DW,Burne THJ,et al.Gestational vitamin D deficiency and autism-related traits:the Generation R Study[J].Mol Psychiatr,2018.doi:10.1038/mp.2016.213.
[16] Mónica López-Vicente,Sunyer J,Lertxundi N,et al.Maternal circulating vitamin D levels during pregnancy and behaviour across childhood[J].Sci Rep,2019,9:14792.
[17] Altun H,Kurutas EB,Sahin N,et al.The levels of vitamin D,vitamin D receptor,homocysteine and complex B vitamin in children with autism spectrum disorders[J].Cli Psychopharm Neur,2018,16(4):383-390.
[18] Zhang Z,Li S,Yu L,et al.Polymorphisms in vitamin D receptor genes in association with childhood autism spectrum disorder[J].Hindawi Disease,2018.doi:10.1155/2018/7862892.
[19] Mobasheri L,Moossavi SZ,Esmaeili A,et al.Association between vitamin D receptor gene FokI and TaqI variants with autism spectrum disorder predisposition in Iranian population[J].Gene,2019,doi:https://doi.org/10.1016/j.gene.2019.144133
[20] Ali A,Cui X,Eyles D.Developmental vitamin D deficiency and autism:putative pathogenic mechanisms[J].Steroid Biochem Mol Biol,2018,175:108-118.
[21] Hawes JE,Tseic D,Whitehouse AJ,et al.Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J].Behav Brain Res,2015,286:192-200.
[22] Delucs HF.Vitamin D:historical overview[J].Vitam Horm,2016,100:1-20.
[23] Rossignol DA,Frye RE.A review of research trends in physiological abnormalities in autism spectrum disorders:immune dysregulation,inflammation,oxidative stress,mitochondrial dysfunction and environmental toxi-cant exposures[J].Mol Psychiatr,2012,17:389-401.
[24] Pertile RAN,Cui X,Hammond L,et al.Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons[J].Faseb J,2018,32(2):819-828.
[25] Patrick RP,Ames BN.Vitamin D hormone regulates serotonin synthesis.Part 1:Relevance for autism[J].FASEB Journal,2014,28:2398-2413.
[26] Saad K,Abdel-Rahman AA,Elserogy YM,et al.Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder[J].Child Psychol Psychiatry,2018,59(1):20-9.
[27] Feng J,Shan L,Du L,et al.Clinical improvement following vitamin D3 supplementation in autism Spectrum disorder[J].Nutr Neurosci,2016,20(5):284-290.
[28] Yamasue H,Okada T,Munesue T,et al.Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder:a randomized clinical trial[J].Molecular Psychiatry,2018,23(8):1-10.
[29] Mazahery H,Conlon CA,Beck KL,et al.A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder[J].J Steroid Biochem,2019.doi:/10.1016/j.jsbmb.2018.10.017.
[30] Feiyong Jia,Ling Shan,Bing Wang,et al.Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children:three cases report[J].Nutr Neurosci,2018.doi:10.1080/1028415X.2018.1458421
[31] Conor PK,Basil E,Peter G,et al.Blunted serum 25-(OH)D response to vitamin D3 supplementation in children with autism[J].Nutr Neurosci,2018.doi:10.1080/1028415X.2018.1529342.
[32] Fraguas D,Díaz-Caneja CM,Pina-Camacho L,et al.Dietary interventions for autism spectrum disorder:a Meta-analysis[J].Pediatrics,2019,144(5):e20183218.
[33] Geir B,Waly MI,Al-Farsi Y,et al.The role of vitamins in autism spectrum disorder:what do we know[J].J Mol Neurosci,2019.doi:/10.1007/s12031-018-1237-5.
[34] Roberta R,Jacques RN,Gesivaldo S,et al.Impact of vitamin deficiency on microbiota composition and immunomodulation:relevance to autistic spectrum disorders[J].Nutr Neurosci,2019.doi:10.1080/1028415X.2019.1660485.

维生素D在孤独症谱系障碍中作用的研究进展

Research advances on the role of vitamin D in autism spectrum disorders

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[2]	刘安南, 姜志梅. 孤独症谱系障碍各年龄段筛查工具研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 645-649.
[3]	黎梦晗, 李廷玉. 孤独症谱系障碍儿童感觉异常的研究进展[J]. 中国儿童保健杂志, 2023, 31(6): 650-655.
[4]	刘梦姣, 郑小琴, 孟仙, 吴晓玲, 葛冬梅, 聂晶. 2~5岁孤独症谱系障碍、疑似孤独症谱系障碍及全面发育迟缓儿童的智能特征分析[J]. 中国儿童保健杂志, 2023, 31(6): 668-673.
[5]	李德欣, 陈强, 庄志成, 陈红, 杨秉娇, 姜顺香, 周翔. 孤独症谱系障碍儿童肠道菌群与症状严重程度相关性研究[J]. 中国儿童保健杂志, 2023, 31(5): 497-501.
[6]	李嘉, 张延赤. 维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 516-520.
[7]	刘佳敏, 赵莎, 钟燕. 外泌体与儿童神经精神障碍的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 521-525.
[8]	刘金, 张芳, 王建忠. 脑瘫患儿血清25-羟维生素D水平与小腿骨骼肌发育及粗大运动功能量表评分的关系[J]. 中国儿童保健杂志, 2023, 31(5): 541-545.
[9]	夏正龙, 宋燕燕. 支气管肺发育不良早产儿神经发育研究[J]. 中国儿童保健杂志, 2023, 31(4): 390-394.
[10]	王娜, 李晓莺. 早产儿神经发育评估的进展[J]. 中国儿童保健杂志, 2023, 31(4): 404-407.
[11]	叶夕霞, 朱之心, 陈明明, 张雅琴, 周静, 曹文婷. 儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析[J]. 中国儿童保健杂志, 2023, 31(4): 416-421.
[12]	王少雯, 张贻霞, 陈静静, 魏秀丽, 叶蓓, 方拴锋. Gesell发展诊断量表在语言相关的发育性疾病中的应用[J]. 中国儿童保健杂志, 2023, 31(4): 442-445.
[13]	陈峰, 张宇. 多胞胎和单胞胎早产儿神经发育的回顾性研究[J]. 中国儿童保健杂志, 2023, 31(4): 451-456.
[14]	柯晓燕. 孤独症谱系障碍早期识别与早期诊断的现状与挑战[J]. 中国儿童保健杂志, 2023, 31(3): 238-240.
[15]	宋超, 胡莉菲, 吴玲玲, 江忠权. 孤独症谱系障碍儿童合并智力功能缺陷的GBM预测模型构建与评价[J]. 中国儿童保健杂志, 2023, 31(3): 241-245.