journal1 ›› 2014, Vol. 22 ›› Issue (7): 771-772.DOI: 10.11852/zgetbjzz2014-22-07-34

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Study on relationship of s-NSE and different serum indexes in neonates with hyperbilirubinemia.

CHEN Bao-chang1, DAI Lan-fen2, REN Chang-jun1, ZHANG Jing1   

  1. 1 Department of Pediatrics, the First Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050031, China;
    2 Department of Pediatrics, The Chidren′Hospital of Hebei Province, Shijiazhuang, Hebei 050031, China
  • Received:2013-11-04 Online:2014-07-10 Published:2014-07-10
  • Contact: DAI Lan-fen, E-mail:2208645694@qq.com

足月新生儿高胆红素性脑损伤不同血清指标的临床意义

陈宝昌1, 戴兰芬2, 任常军1, 张晶1   

  1. 1 河北医科大学第一医院儿科, 河北 石家庄 050031;
    2 河北省儿童医院儿内科, 河北 石家庄 050031
  • 通讯作者: 戴兰芬, E-mail:2208645694@qq.com
  • 作者简介:陈宝昌(1964-), 男, 河北人, 主任医师, 研究方向为新生儿疾病。
  • 基金资助:
    河北省科技攻关课题(052761629)

Abstract: Objective To explore relationships of serum neuron-specific enolase (NSE) and serum bilirubin, albumin and B/A values, in neonates suffering from hyperbilirubin-induced brain injury. Methods Serum NSE contents (s-NSE)of hyperbilirubinemia infants were determined by ELISA.Serum indirect bilirubin values (s-UCB) and albumin values (A) were measured by full-automatic biochemical analyzerm, and indirect bilirubin and albumin ratio (B/A) was calculated.The 62 cases with increased s-NSE concentrations were devided into two groups:mildly increased s-NSE values group and highly increased s-NSE values group, then differences of serum indicators from the two groups, and correlations of s-NSE values and the serum indicators were analyzed. Results There were significant difference in s-UCB value (P<0.05), no significant difference in A values (P>0.05), and very significant difference in B/A value (P<0.001) between two groups.There was a good positive correlation between s-NSE value and the B/A value (r=0.687, P<0.001). Conclusions B/A ratio could be a good mark to hyperbilirubin-induced brain injury.Through monitoring B/A ratio, neonates with hyperbilirubinemia may reasonably be intervened.

Key words: bilirubin, serum indexes, brain injury, neonate

摘要: 目的 研究新生儿胆红素性脑损伤患儿血清神经元特异性烯醇化酶(serum neuron-specific enolase, s-NSE)含量与血清胆红素、白蛋白及B/A值的关系。方法 采用ELISA法测定高胆红素血症新生儿血清s-NSE含量, 全自动生化分析仪测定其血清间接胆红素数值(UCB)、白蛋白数值(A), 计算间接胆红素与白蛋白的比值(B/A);将62例s-NSE含量增高患儿分成两组:s-NSE值轻度增高组和s-NSE值重度增高组, 分析两组血清指标的差异, 以及s-NSE值与各指标的相关性。结果 两组间UCB值差异有统计学意义(P<0.05), A值无统计学意义(P>0.05), B/A值差异有统计学意义(P<0.001); s-NSE值与B/A值呈高度正相关性(r=0.687, P<0.001)。结论 B/A比值能较好的反应胆红素性脑损害, 临床可通过对B/A值的监测, 指导高胆红素血症患儿的合理干预。

关键词: 胆红素, 血清指标, 脑损伤, 新生儿

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