Abstract: Objective To study the sialic acid (SA) levels in breast milk collected from early neonate's mother, and provide the scientific basis for early breast-milk feeding in neonate especially in pre-term neonates. Methods A total of 284 breast milk samples were collected from 122 early neonate's mothers at the 1^st, 4^th and 6^th days after delivery.The SA levels in breast milk were tested with neuraminidase assay method, the statistical analysis software, SPSS version 17.0 was used in the study.Independent sample T test was used to compare SA levels between groups and Pearson correlation analysis method was used to analyze correlation. Results The mean SA levels in the 1^st day breast milk was (208.6±71.6)mg/dL, which was significantly higher than that in the 4^th day breast milk [(140.4±36.6) mg/dL;t=8.100, P<0.001] and the 6^th day breast milk [(139.3±37.8) mg/dL;t=8.089, P<0.001], however, no difference was found between the 4^th day and 6^th day breast milk(t=0.197, P=0.844).A strong negative correlation between SA levels in breast milk and days after delivery in women was identified, however, no correlation was found between SA levels and birth weights or gestational ages. Conclusion The SA levels is the highest in the 1^st day breast milk and SA levels in brest milk are strongly correlated with the days after delivery in women.

Key words: breast milk, sialic acid, neonate

摘要： 目的 研究早期新生儿母亲乳汁中唾液酸水平, 为母乳喂养儿尤其早产儿尽早开奶提供科学依据。方法 收集122例早期新生儿母亲产后第1、4、6天母乳共284份, 用神经氨酸苷酶法检测母乳唾液酸水平, 统计分析采用SPSS软件17.0版, 组间比较采用独立样本的t检验, 相关性采用Pearson相关分析法。结果 早期新生儿母亲产后第1天、第4天和第6天母乳中唾液酸含量分别为(208.6±71.6)mg/dL、(140.4±36.6) mg/dL和(139.3±37.8) mg/dL, 第1天唾液酸含量显著高于第4天(t=8.100, P<0.001)和第6天(t=8.089, P<0.001)的母乳, 但第4天与第6天母乳中唾液酸水平差异无统计学意义(t=0.197, P=0.844)。母乳唾液酸水平与日龄负相关(r=-0.433, P<0.001), 与胎龄(r=0.049, P=0.450)和出生体重(r=0.059, P=0.340)无明显相关。结论 早期新生儿母亲第1天乳汁中唾液酸含量最高, 母乳唾液酸水平与日龄负相关。

关键词: 母乳, 唾液酸, 新生儿