Abstract: Objective To investigate the levels and deficiency of 25-hydroxy vitamin D[25-(OH)D] in children at 0~16 years old in Nanjing area. Method Serum levels of 25-(OH)D in 2 266 cases of children at 0~16 years old,detected by enzyme linked immunosorbent assay (ELISA) between April 2012 and March 2013,were statistically analyzed. Results 1) Among 1 204 cases of children in winter and spring,the serum level of 25-(OH)D was (55.1±19.58)nmol/L (male 778,female 426),there had no statistical difference between different gender groups.And there had statistical difference among group lower than 1 year old [(71.7±27.39)nmol/L],group 1~7 years old[(59.6±18.25)nmol/L] and group more than 7 years old[(46.9±14.97)nmol/L].2) Among 1 062 cases of children in summer and autumn,the serum level of[25-(OH)D] was (67.2±46.89) nmol/L ( male 670,female 392 ),there had no statistical difference between different gender groups.And there had statistical difference among group lower than 1 year old [(98.0±39.97)nmol/L],group 1~7 years old [(73.0±61.73)nmol/L] and group more than 7 years old [(55.8±16.75)nmol/L].3)There had statistical difference between different season groups (P<0.01). Conclusion The serum levels of 25-(OH)D of 0~16 years old are sub clinic deficiency except group lower than 1 year old in Summer and Autumn.And the serum levels of 25-(OH)D decrease gradually by the age of children increasing.

Key words: vitamin D, nutritional status, child

摘要： 目的 了解0~16岁儿童维生素D营养状况。方法 对在南京儿童医院儿童保健科门诊进行常规体检的0~16岁2 266例儿童采用酶联免疫法进行血清25-(OH)D检测。结果 1)冬春季检测1 204例,血清25-(OH)D为(55.1±19.58)nmol/L,男778例,女426例,血清25-(OH)D分别为(55.2±20.83)和(55.0±19.95)nmol/L,差异无统计学意义;其中≤1岁组、1~7岁组和>7岁组血清25-(OH)D分别为(71.7±27.39)、(59.6±18.25)和(46.9±14.97)nmol/L,组间两两比较均有统计学意义(P<0.01)。2)夏秋季检测1 062例,血清25-(OH)D为(67.2±46.89)nmol/L,男670例,女392例,血清25-(OH)D分别为(67.8±51.51)和(68.3±35.21)nmol/L,差异无统计学意义;其中≤1岁组、1~7岁组和≥7岁组,血清25-(OH)D分别为(98.0±39.97)、(73.0±61.73)和(55.8±16.75)nmol/L,组间两两比较差异均有统计学意义(P<0.01)。3)日照不足的冬春季儿童的血清25-(OH)D水平显著低于日照充足的夏秋季(P<0.01)。结论 0~16岁儿童除夏秋季婴儿组外,其余各年龄组全年的维生素D营养状况均属于不足的水平,并且年龄越大,维生素D水平越低,应该增加南京市儿童维生素D摄入量及延长户外活动时间,尤需重视7岁以上儿童及冬春季维生素D的补充。

关键词: 维生素D, 营养状况, 儿童