Research progress in the association of milk
fat globule membrane with infants’ brain development and health

doi:10.11852/zgetbjzz2016-24-01-13

Abstract

摘要： 母乳和牛乳中的脂肪均以脂肪球的形式均匀分散在乳汁中,形成乳脂的特殊状态。乳脂在乳腺细胞合成、分泌过程中逐渐形成具有独特的3层膜结构包裹的乳脂球。包裹脂肪球的膜性结构被称为乳脂球膜(milk fat globule membrane,MFGM)。近年的研究发现, MFGM的主要成分是多种磷脂和特殊膜蛋白,对于婴幼儿的神经发育、代谢调节、抗感染等均具有重要作用。本文查阅和梳理了有关乳脂球膜研究文献,总结了乳脂球膜的对婴幼儿脑发育和生长的健康效应,为进一步推广母乳喂养及更广阔的用途提供科学依据。

关键词: 乳脂球膜, 脑发育, 认知能力, 代谢调节, 健康效应, 婴幼儿

CLC Number:

R179

ZHANG Bo, SU Yi-xiang, YANG Yu-feng.

Research progress in the association of milk fat globule membrane with infants’ brain development and health [J]. Chinese Journal of Child Health Care, 2016, 24(1): 43-47.

张波综述, 苏宜香, 杨玉凤审校. 乳脂球膜与婴幼儿脑发育及健康的研究进展[J]. 中国儿童保健杂志, 2016, 24(1): 43-47.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2016-24-01-13

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2016/V24/I1/43

References

[1] Anderson JW,Johnstone BM,Remley DT.Breast-feeding and cognitive development:a meta-analysis[J].Am J Clin Nutr 1999,70(4):525-535.
[2] Lucas A,Morley R,Cole TJ.Randomised trial of early diet in preterm babies and later intelligence quotient[J].BMJ,1998,317(7171):1481-1487.
[3] Owen CG,Whincup PH,Kaye SJ,et al.Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence[J].Am J Clin Nutr,2008,88(2):305-314.
[4] Horta BL,de Mola CL,Victora CG.Long-term consequences of breastfeeding on cholesterol,obesity,systolic blood pressure,and type-2 diabetes:systematic review and meta-analysis[J].Acta Paediatr,2015,doi:10.1111/apa.13133.
[5] Owen CG,Martin RM,Whincup PH,et al.Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence[J].Am J Clin Nutr,2006,84(5):1043-1054.
[6] Keenan TW,Morre DJ,Olson DE,et al.Biochemical and morphological comparison of plasma membrane and milk fat globule membrane from bovine mammary gland[J].J Cell Biol,1970,44(1):80-93.
[7] Spitsberg VL.Invited review:Bovine milk fat globule membrane as a potential nutraceutical[J].J Dairy Sci,2005,88(7):2289-2294.
[8] Michalski MC,Ollivon M,Briard V,et al.Native fat globules of different sizes selected from raw milk:thermal and structural behavior[J].Chem Phys Lipids,2004,132(2):247-261.
[9] Heid HW,Keenan TW.Intracellular origin and secretion of milk fat globules[J].Eur J Cell Biol,2005,84(2-3):245-258.
[10] Jaap ME,Stephen EH,Geoffrey BJ,et al.Heterogeneity of milk fat globule membrane structure and composition as observed using fluorescence microscopy techniques[J].International Dairy Journal,2008,18(12):1081-1089.
[11] Singh H.The milk fat globule membrane-A biophysical system for food applications[J].Curr Opin Colloid Interface Sci,2006,11(2-3):154-163.
[12] Dewettinck K,Rombaut R,Thienpont N,et al.Nutritional and technological aspects of milk fat globule membrane material[J].Int Dairy J,2008,18(5):436-457.
[13] Gallier S,Gragson D,Jimenez-Flores R,et al.Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins[J].J Agric Food Chem,2010,58(7):4250-4257.
[14] Deeth HC.The role of phospholipids in the stability of milk fat globules[J].Aust J Dairy Technol,1997,52:44-46.
[15] Garcia C,Lutz NW,Confort-Gouny S,et al.Phospholipid fingerprints of milk from different mammalians determined by 31P NMR:towards specific interest in human health[J].Food Chem,2012,135(3):1777-1783.
[16] Reinhardt TA,Lippolis JD.Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk[J].J Dairy Sci,2008,91(6):2307-2318.
[17] El-Loly M.Composition,properties and nutritional aspects of milk fat globule membrane-a review[J].Polish Journal of Food and Nutrition Sciences,2011,61(1):7-32.
[18] Abderrahmane FM-M,Jean-Michel G,Elie F,et al.Mitogenic activity of hydrophobic fractions of proteose peptone from cows',ewes' and goats' milk measured with MARK 3 hybridoma culture[J].Journal of Dairy Research,1993,60(3):443-448.
[19] Pallesen LT,Pedersen LR,Petersen TE,et al.Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk[J].J Dairy Sci,2007,90(7):3143-3152.
[20] Timby N,Domellof E,Hernell O,et al.Neurodevelopment,nutrition,and growth until 12 mo of age in infants fed a low-energy,low-protein formula supplemented with bovine milk fat globule membranes:a randomized controlled trial[J].Am J Clin Nutr,2014,99(4):860-868.
[21] Veereman-Wauters G,Staelens S,Rombaut R,et al.Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children[J].Nutrition,2012,28(7-8):749-752.
[22] Tanaka K,Hosozawa M,Kudo N,et al.The pilot study:sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy,randomized control trial[J].Brain Dev,2013,35(1):45-52.
[23] Gurnida DA,Rowan AM,Idjradinata P,et al.Association of complex lipids containing gangliosides with cognitive development of 6-month-old infants[J].Early Hum Dev,2012,88(8):595-601.
[24] Liu H,Radlowski EC,Conrad MS,et al.Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets[J].J Nutr,2014,144(12):1903-1909.
[25] Patel MS,Srinivasan M,Laychock SG.Metabolic programming:Role of nutrition in the immediate postnatal life[J].J Inherit Metab Dis,2009,32(2):218-228.
[26] Owen CG,Whincup PH,Gilg JA,et al.Effect of breast feeding in infancy on blood pressure in later life:systematic review and meta-analysis[J].BMJ,2003,327(7425):1189-1195.
[27] Owen CG,Whincup PH,Odoki K,et al.Infant feeding and blood cholesterol:a study in adolescents and a systematic review[J].Pediatrics,2002,110(3):597-608.
[28] Timby N,Lonnerdal B,Hernell O,et al.Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes[J].Pediatr Res,2014,76(4):394-400.
[29] Zavaleta N,Kvistgaard AS,Graverholt G,et al.Efficacy of an MFGM-enriched complementary food in diarrhea,anemia,and micronutrient status in infants[J].J Pediatr Gastroenterol Nutr,2011,53(5):561-568.
[30] Timby N,Hernell O,Vaarala O,et al.Infections in infants fed formula supplemented with bovine milk fat globule membranes[J].J Pediatr Gastroenterol Nutr,2015,60(3):384-389.
[31] Stefferl A,Schubart A,Storch M,et al.Butyrophilin,a milk protein,modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis[J].J Immunol,2000,165(5):2859-2865.
[32] Newburg DS.Human milk glycoconjugates that inhibit pathogens[J].Curr Med Chem,1999,6(2):117-127.
[33] Saeland E,de Jong MA,Nabatov AA,et al.MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells[J].Mol Immunol,2009,46(11-12):2309-2316.
[34] Cleary TG.Human milk protective mechanisms[J].Adv Exp Med Biol,2004,554:145-154.
[35] Billeaud C,Puccio G,Saliba E,et al.Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas:a randomized controlled multicenter non-inferiority trial in healthy term infants[J].Clin Med Insights Pediatr 2014,8:51-60.
[36] Timby N,Domellof M,Lonnerdal B,et al.Comment on "safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas:A randomized controlled multicenter non-inferiority trial in healthy term infants"[J].Clin Med Insights Pediatr,2015,9:63-64.

Research progress in the association of milk fat globule membrane with infants’ brain development and health

乳脂球膜与婴幼儿脑发育及健康的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	XIANG Wei. Early prevention of dyslipidemia in children and adolescents as well as cardiovascular health in adulthood [J]. Chinese Journal of Child Health Care, 2023, 31(7): 697-702.
[2]	WU Ting, LI Fei. Adverse factors in early life and the development and prevention of chronic diseases [J]. Chinese Journal of Child Health Care, 2023, 31(7): 703-706.
[3]	LIU Min, ZHANG Qian, YANG Ting, CHEN Jie, CHEN Li, DAI Ying, JIA Feiyong, WU Lijie, HAO Yan, LI Ling, ZHANG Jie, KE Xiaoyan, YI Mingji, HONG Qi, CHEN Jinjin, FANG Shuanfeng, WANG Yichao, WANG Qi, JIN Chunhua, LI Tingyu. Multi-center survey on serum folic acid in preschool children in China [J]. Chinese Journal of Child Health Care, 2023, 31(7): 713-717.
[4]	HUO Yanyan, LIU Zhongling, MA Ling, WU Dan, WANG Xiulian, QIU Xiaoyan, DOU Jiaying, REN Yuqian, LI Yicheng, HONG Xia, CHEN Jinjin. Status quo and risk factors for different body proportions of children under 2 years old in the real world [J]. Chinese Journal of Child Health Care, 2023, 31(7): 718-723.
[5]	YANG Yuru, WANG Hong, XU Shuhong, CAO Yanmei, MENG Xian, GE Dongmei. Association between bone development and vitamin K in children aged 0 to 14 years [J]. Chinese Journal of Child Health Care, 2023, 31(7): 746-750.
[6]	LI Mingzhu, WANG Jing, XIE Duoshuang. Research progress in the relationship between rapid catch-up growth and childhood obesity in small for gestational age infants [J]. Chinese Journal of Child Health Care, 2023, 31(7): 751-755.
[7]	CAO Hui, YAN Shuangqin, GUAN Hongyan. Influence of parent-child interaction on early childhood development outcome [J]. Chinese Journal of Child Health Care, 2023, 31(7): 770-774.
[8]	SUN Yan, GUO Fei , CHEN Zhiyan. Chain mediating role of family home reading and mother-child intimacy in intergenerational transmission of emotion regulation strategy [J]. Chinese Journal of Child Health Care, 2023, 31(6): 606-611.
[9]	ZHOU Yuanke, LI Yueyue, FANG Bo, SHENG Lulu, WU Wenyi, XI Xuan, LIU Qin. Behavior changes and influencing factors of firstborn children before and after the birth of the second children in a district of Chongqing [J]. Chinese Journal of Child Health Care, 2023, 31(6): 617-622.
[10]	TIAN Tian, SONG Jia, LI Jing, YUAN Hui, SHEN Mengmeng, DING Rong, ZHU Xiaohua, XU Hongze, HU Youfang. Family rearing environment and behavior problems of the second child aged 4 to 6 years in Jiangsu Province [J]. Chinese Journal of Child Health Care, 2023, 31(6): 623-628.
[11]	WANG Ziyang, HU Lei, LIU Jintong. Associations between family relationship and children's sleep [J]. Chinese Journal of Child Health Care, 2023, 31(6): 640-644.
[12]	WANG Dan, HUANG Chuican, FAN Lichun. Research progress in the effects of responsive feeding on sleep of infants and young children [J]. Chinese Journal of Child Health Care, 2023, 31(6): 656-660.
[13]	YU Yabin, WANG Jianhong, XU Qi, WANG Lei, ZHOU Bo, ZHANG Lili, WANG Xi, WANG Lin. Influencing factors of children with developmental stuttering [J]. Chinese Journal of Child Health Care, 2023, 31(6): 674-677.
[14]	LIANG Yijia, WU Honglin, HE Xiumei, HU Xiaohong, HE Xiyu. Types and frequencies of gene variants in idiopathic short stature children [J]. Chinese Journal of Child Health Care, 2023, 31(6): 678-683.
[15]	YING Jiali, CHEN Xiuqin, YANG Chen, HUANG Limei, YU Yan, GAO Xuemei. Moderating role of personality traits in the influence of violent video games on adolescent aggressive behavior [J]. Chinese Journal of Child Health Care, 2023, 31(6): 684-688.