journal1 ›› 2016, Vol. 24 ›› Issue (2): 188-190.DOI: 10.11852/zgetbjzz2016-24-02-23

• Original Articles • Previous Articles     Next Articles

Role of serum ghrelin on myocardial hypoxia inflammation in children with tetralogy of Fallot

ZHAO Xiao-jie1,GENG Yu-lan1,ZHAO-jing1,CHEN Zheng-li1,LI Xiao-bing2,LI Mei3   

  1. 1 Department of Clinical Laboratory,First Hospital of Hebei Medical University,Shijiazhuang,Hebei 050031,China;
    2 Diagnosis and Treatment Center of Congenital Heart Disease,First Hospital of Hebei Medical University, Shijiazhuang,Hebei 050031,China;
    3 Department of Clinical Laboratory, Hebei Provinced Children Hospital,Shijiazhuang,Hebei 050031,China
  • Received:2015-08-07 Online:2016-02-01 Published:2016-02-01
  • Contact: LI Mei,



  1. 1 河北医科大学第一医院检验科,河北 石家庄 050031;
    2 河北医科大学第一医院心脏诊疗中心,河北 石家庄 050031;
    3 河北省儿童医院检验科,河北 石家庄 050031
  • 通讯作者: 李梅,
  • 作者简介:赵小洁(1980-),女,河北人,主管检验技师,学士学位,主要研究方向为先心病的实验室诊断。
  • 基金资助:

Abstract: Objective To investigate the roles of both serum ghrelin and high-sensibivity CRP (hs-CRP) on myocardial hypoxia inflammation in children with tetralogy of Fallot(TOF). Method Serum which were collected from children with TOF (TOF group,n=60) from our Diagnosis and Treatment Center of Congenital Heart Disease from January,2011 to May,2015 and healthy children(control group,n=30) in the same period were examined for ghrelin and hs-CRP.Serum concentrations of both ghrelin and hs-CRP of two groups were compared while their correlation were analyzed. Result The levels of both ghrelin and hs-CRP in children with TOF groups were significantly higher than these in controls (P<0.01),and ghrelin had positive correlation with hs-CRP. Conclusion Serum ghrelin in children with TOF is positively correlated with serum hs-CRP,which suggests that serum ghrelin plays certain protection role on myocardial hypoxia inflammation in children with TOF.

Key words: tetralogy of Fallot, congenital heart disease, ghrelin, high-sensitivity CRP

摘要: 目的 探讨血清胃饥饿素(ghrelin)和超敏C反应蛋白(high-sensibivity CRP,hs-CRP)在法洛四联症(tetralogy of Fallot,TOF)患儿心肌缺氧炎症反应中的作用。方法 收集本院心脏诊疗中心2012年1月-2014年5月期间60例青紫型TOF患儿及30例同期健康体检儿童静脉血,检测血清ghrelin和hs-CRP浓度。比较两组儿童ghrelin和hs-CRP水平并进行相关性分析。结果 TOF患儿组血清ghrelin和hs-CRP水平显著高于正常对照组(P<0.01),且两者呈正相关(P<0.01)。结论 法洛四联症患儿血清ghrelin和hs-CR水平升高且呈正相关,提示ghrelin在法洛四联症患儿缺氧导致的心肌炎症反应中具有一定的保护作用。

关键词: 法洛四联症, 先天性心脏病, 胃饥饿素, 超敏C反应蛋白

CLC Number: