Abstract: Objective To investigate the roles of both serum ghrelin and high-sensibivity CRP (hs-CRP) on myocardial hypoxia inflammation in children with tetralogy of Fallot(TOF). Method Serum which were collected from children with TOF (TOF group,n=60) from our Diagnosis and Treatment Center of Congenital Heart Disease from January,2011 to May,2015 and healthy children(control group,n=30) in the same period were examined for ghrelin and hs-CRP.Serum concentrations of both ghrelin and hs-CRP of two groups were compared while their correlation were analyzed. Result The levels of both ghrelin and hs-CRP in children with TOF groups were significantly higher than these in controls (P<0.01),and ghrelin had positive correlation with hs-CRP. Conclusion Serum ghrelin in children with TOF is positively correlated with serum hs-CRP,which suggests that serum ghrelin plays certain protection role on myocardial hypoxia inflammation in children with TOF.

Key words: tetralogy of Fallot, congenital heart disease, ghrelin, high-sensitivity CRP

摘要： 目的 探讨血清胃饥饿素(ghrelin)和超敏C反应蛋白(high-sensibivity CRP,hs-CRP)在法洛四联症(tetralogy of Fallot,TOF)患儿心肌缺氧炎症反应中的作用。方法 收集本院心脏诊疗中心2012年1月-2014年5月期间60例青紫型TOF患儿及30例同期健康体检儿童静脉血,检测血清ghrelin和hs-CRP浓度。比较两组儿童ghrelin和hs-CRP水平并进行相关性分析。结果 TOF患儿组血清ghrelin和hs-CRP水平显著高于正常对照组(P<0.01),且两者呈正相关(P<0.01)。结论 法洛四联症患儿血清ghrelin和hs-CR水平升高且呈正相关,提示ghrelin在法洛四联症患儿缺氧导致的心肌炎症反应中具有一定的保护作用。

关键词: 法洛四联症, 先天性心脏病, 胃饥饿素, 超敏C反应蛋白