Abstract: Objective To analyze the main causes and early comprehensive intervention effects of the patients with Global developmental delay (GDD),and determine the in neurobehavioral development prognosis of them. Methods Totally 33 cases GDD hospitalized children with comprehensive intervention in the GDD were early intervention group,31 non-hospitalized cases that were for only the family intervention without comprehensive intervention,were the control group.The etiology was analyzed,and individual treatment was plan designed according to different etiology.Before and after the intervention,the GESELL Developmental Scale was used to determine the developmental quotient(DQ) for the statistical analysis,and the efficacy evaluation. Results Before intervention,there was no significant difference between the two groups.6 months later,the DQ of the intervention group was (72.20±15.56),which was significantly higher than that (59.98±14.61) before intervention and that (62.51±13.95) of the control group,the effect of the intervention group was significantly better than the control group(P<0.05),there were statistically significant differences.Neonatal hypoxic-ischemic encephalopathy (HIE),premature birth,intrauterine growth retardation and neonatal asphyxia were the common causes of GDD.The DQ in GDD children with single pathogenic factor was better than that in children with multiple factors. Conclusion s Comprehensive early intervention and individual treatment plan can significantly improve the DQ and the prognosis of the children with GDD.Strengthening perinatal health care has great significance to prevent and treat the GDD.

Key words: global developmental delay, etiological, comprehensive intervention, development quotient, effect

摘要： 目的 分析全面性发育迟缓(GDD)患儿的主要病因和早期综合干预疗效,以及判断其神经行为发育预后情况。方法 33例住院进行综合性干预的GDD患儿为综合干预组,31例未住院进行综合性干预,仅指导家庭干预的患儿为对照组。分析其病因,结合不同病因设计个体治疗方案,并在干预前后应用GESELL发育量表测定发育商(DQ)进行统计分析,评价疗效。结果 治疗干预前,两组患儿一般情况差异无统计学意义,6个月后综合干预组患儿DQ为(72.20±15.56),明显高于治疗前的(59.98±14.61)和对照组的(62.51±13.95),干预组疗效评估亦明显优于对照组,差异有统计学意义(P均<0.05)。新生儿HIE、早产、宫内发育迟缓和新生儿窒息是GDD的常见病因。单致病因素所致GDD患儿的DQ发育优于多致病因素GDD患儿。结论 综合性早期干预,结合病因设计个体治疗方案可明显提高GDD患儿的DQ,改善其预后。加强围生期保健,对防治GDD具有重要的意义。

关键词: 全面性发育迟缓, 病因, 综合干预, 发育商, 疗效