Advances in the research of the immune mechanism of asthma in infants with bronchiolitis

doi:10.11852/zgetbjzz2017-25-10-14

journal1 ›› 2017, Vol. 25 ›› Issue (10): 1027-1029.DOI: 10.11852/zgetbjzz2017-25-10-14

Previous Articles Next Articles

Advances in the research of the immune mechanism of asthma in infants with bronchiolitis

ZHI Yu-ping¹,HE Xue-ming²,DONG Qing³

1 Department of Pediatrics;
2Department of Cardiology;
3 Department of Newborn,Lianyungang Oriental Hospital Affiliated to Bengbu Medical College,Lianyungang,Jiangsu 222042,China

Received:2016-11-05 Online:2017-10-10 Published:2017-10-10
Contact: DONG Qing,E-mail:dqshmu@sina.com

婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展

智玉萍¹,何学明²,董青³

蚌埠医学院附属连云港东方医院 1儿科,2心内科,3新生儿科,江苏连云港 222042

通讯作者: 董青,E-mail:dqshmu@sina.com
作者简介:智玉萍(1989-),女,山东人,研究生,硕士学位,主要研究方向为儿内科呼吸系统。
基金资助:
蚌埠医学院创新课题(Byycx1516)

Abstract

Abstract: Bronchiolitis,a common lower respiratory tract infection in infants,is a major cause of infant hospitalization.Also,bronchiolitis is often considered the first attack of asthma,and has a close relationship with asthma,but its mechanism is still not clear.In recent years,the change of capillary bronchitis in infants and young children has a great progress,mainly in the field of immunology.This article reviews the progress of imm-unology in recent years,in order to provide reference for basic research and clinical diagnosis and treatment.

Key words: bronchiolitis, asthma, immune, cell factor

摘要： 毛细支气管炎是婴幼儿住院的一个重要原因,属于一种婴幼儿较常见的下呼吸道感染,通常被认为是哮喘的第一次发作,与哮喘有着密切的关系,但其主要机制仍不清楚。近年来婴幼儿毛细支气管炎转变为哮喘的机制有较大进展,主要集中在免疫学领域。本文就近年免疫学方面的进展进行综述,以期为基础研究和临床诊疗提供参考。

关键词: 毛细支气管炎, 哮喘, 免疫, 细胞因子

CLC Number:

R179

ZHI Yu-ping,HE Xue-ming,DONG Qing. Advances in the research of the immune mechanism of asthma in infants with bronchiolitis[J]. journal1, 2017, 25(10): 1027-1029.

智玉萍,何学明,董青. 婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展[J]. 中国儿童保健杂志, 2017, 25(10): 1027-1029.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2017-25-10-14

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2017/V25/I10/1027

References

[1] Midulla F,Pierangeli A,Cangiano G,et al.Rhinovirus bionchiolitis and recurrent wheezing:1-year follow-up[J].Eur respir,2012,39(2):396-402.
[2] Omari K E,Dhaliwal B,Ren J,et al.Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms:details of potential packing interactions in the native helical form[J].Acta Crystallogr Sect F Struct Biol Cryst Commun,2011,67(10):1179-1183.
[3] 宋文秀,何月贤,赵维笑.LTC4S基因多态性与呼吸道合胞病毒毛细支气管炎的相关性[J].广东医学,2015,36(9):1380-1383.
[4] 顾坚,雷尚兵,张仕超,等.干扰素联合雾化吸入对毛细支气管炎患儿肺功能的影响[J].浙江临床医学,2014,16(5):735-736.
[5] Carbonellestrany X,Simes EA,Dagan R,et al.Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children:a noninferiority trial [J].Pediatrics,2010,125(1):e35-e51.
[6] 周晓英.孟鲁司特钠治疗婴幼儿毛细支气管炎的疗效及对反复喘息的预防效果[J].中国临床药学杂志,2011(3):157-159.
[7] Han RF,Li HY,Wang JW,et al.Study on clinical effect and immunologic mechanism of infants capillary bronchitis secondary bronchial asthma treated with bacterial lysates Broncho-Vaxom[J].Eur Rev Med Pharmaco,2016,20(10):2151-2155.
[8] 平雯,章建伟,钟永兴.孟鲁司特钠对毛细支气管炎后喘息的治疗及预防作用[J].中国现代医生,2013,51(25):156-157.
[9] Zaid AN,Abualhasan MN,Watson DG,et al.Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method[J].Drug Des Devel Ther,2015,23(9):5315-5321.
[10] O'Shea JJ,Plenge R.JAK and STAT signaling molecules in immunoregulation and immune-mediated disease[J].Immunity,2012,36(4):542-550.
[11] Wang J,Wu J,Kong L,et al.BuShenYiQi Formula strengthens Th1 response and suppresses Th2-Th17 responses in RSV-induced asthma exacerbated mice[J].J Ethnopharmacol,2014,154(1):131-147.
[12] Zhang G,Zhou KF,Lu ZH.Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophill migration and reducing interferon-gamma expression[J].Genet Mol Res,2016,15(1).doi:10.4238/gmr.15017002
[13] Mukherjee S,Lindell DM,Berlin AA,et al.IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease[J].Am J Pathol,2011,179(1):248-258.
[14] Cautivo KM,Bueno SM,Cortes CM,et al.Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infection [J].J Immunol,2010,185(12):7633-7645. [15] Faber TE,Groen H,Welfing M,et al.Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis[J].J Med Virol,2012,84(7):1084-1088.
[16] Bystrom J,Amin K,Bishop-Bailey D.Analysing the eosinophil cationic protein-a clue to the function of the eosinophil granulocyte[J].Respiratory Research,2011,12(1):1-20.
[17] Choi J,Callaway Z,Kim HB,et al.The role of TNF-α in eosinophilic inflammation associated with RSV bronchiolitis [J].Pediatric Allergy & Immunology,2010,21(3):474-479.

Advances in the research of the immune mechanism of asthma in infants with bronchiolitis

婴幼儿毛细支气管炎发展为哮喘的免疫机制研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	LIU Jiamin, ZHAO Sha, ZHONG Yan. Research advance on exosomes and neuropsychiatric disorders in children [J]. Chinese Journal of Child Health Care, 2023, 31(5): 521-525.
[2]	ZHENG Tingyu, ZHANG Chunyu, YANG Fei, ZHENG Fang, ZHANG Mengxia, XIA Luping, XU Sunchao. Effects of nutrition support team management mode on growth development and immune function in premature infants [J]. Chinese Journal of Child Health Care, 2023, 31(5): 555-558.
[3]	MAI Guohua. Investigation and analysis of influencing factors of self-management behavior in school-age children with bronchial asthma [J]. Chinese Journal of Child Health Care, 2023, 31(4): 446-450.
[4]	LI Yu, ZHAO Jia-hong, KAN Xuan. Clinical application of China Children′s Asthma Action Plan [J]. Chinese Journal of Child Health Care, 2023, 31(2): 185-189.
[5]	WANG Xu, WANG Shu-ying, LI Li, ZOU Ying-xue. Meta-analysis of the risk factors for recurrent wheezing after bronchiolitis [J]. Chinese Journal of Child Health Care, 2023, 31(2): 190-194.
[6]	XU Yan, LIU Dong-hai, LIANG Xuan, GUO Li, DAI Yong-li, ZHANG Rong-fang. Influencing factors of asthma in children from the plateau area [J]. Chinese Journal of Child Health Care, 2022, 30(7): 796-800.
[7]	ZHANG Yu, XIE Xiao-min, MA Tian, TONG Hai-xia, WANG Lei, LI Ge, YU Xia, SHANG Lei, JIANG Xun. Association of disease control with family function, self-management and perceived stress in adolescent children with asthma [J]. Chinese Journal of Child Health Care, 2022, 30(3): 314-318.
[8]	TAO Feng-jiao, WEN Hang-wei, LIU Zuo-jiao. Relationship between serum high mobility group box-1 protein, soluble cluster differentiation 163 levels andfractional exhaled nitric oxide concentration and severity of bronchiolitis in children [J]. Chinese Journal of Child Health Care, 2022, 30(3): 335-338.
[9]	LI Yu, KAN Xuan. Research progress in the application of bacterial lysates in children with respiratory allergic diseases [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1336-1340.
[10]	ZHANG Yang, WANG Hui-yuan, GENG Yan, JIN Qiao-yan, HAO Juan-juan, HOU Wei. Status quo and related factors of emotional problems in children with bronchial asthma [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1400-1403.
[11]	YANG Li-juan, DENG Gao, DING Bo, YANG Li-min, LI Dong-ming, HUANG Yong-fang, LIN Na. Association of ADAM33 gene and its serum level with the risk of asthma in Zhuang children in Guangxi [J]. Chinese Journal of Child Health Care, 2022, 30(11): 1185-1190.
[12]	LI Wan-ying, SONG Chun-lan, SHAN Zhao-qian, XIONG Lei-lei, ZHANG Zhi-ying. Changes and significance of cardiovascular metabolic indicators in children with asthma at different control levels [J]. Chinese Journal of Child Health Care, 2022, 30(11): 1246-1249.
[13]	FU Yan-yan, LIU Wei, XU Li-yuan. Difference in air pollutant concentration between suburbs and urban areas and its correlation with the severity of asthma in children [J]. Chinese Journal of Child Health Care, 2022, 30(11): 1262-1266.
[14]	SHEN Ren, YANG Shan-pu, ZHANG Lin-tao, WU Yue-chao. Relationship between recurrent wheezing and gene prediction model of four-locus asthma in children and risk factors of recurrent wheezing [J]. Chinese Journal of Child Health Care, 2022, 30(10): 1132-1135.
[15]	LI Yu-jian, WANG Yang, KAN Xuan. Meta-analysis of risk factors for acute attack of asthma in Chinese children [J]. Chinese Journal of Child Health Care, 2021, 29(9): 992-995.