Circadian clock and obesity

doi:10.11852/zgetbjzz2018-1170

Abstract

Abstract: The circadian rhythms of physiology and behaviors are driven by an intrinsic machinery called the circadian clock, which generates rhythms with a periodicity of about 24 hours.Accumulating evidence suggest that the disruption of circadian rhythms is closely related to the development of obesity and its clinical complications.However,the mechanism is incompeletely understood.Researches indicate that the circadian clock regulates metabolism and energy homeostasis by affecting rhythmic release of various endocrine hormones and adipokines.Further study on the interaction between the circadian clock and obesity may provide new ideas and therapeutic strategies for the prevention and treatment of obesity,especially childhood obesity

Key words: circadian clock, obesity, intrinsic mechanism, circadian rhythms

摘要： 生物钟调控机体的生理和行为呈现周期为24 h的昼夜节律。越来越多的证据显示昼夜节律的破坏与肥胖及其并发症的发生发展密切相关,但其中的机制尚不明确。大量研究表明生物钟可能通过影响各种内分泌激素及脂肪因子的分泌节律调节机体的新陈代谢及能量稳态。深入研究生物钟与肥胖的相互作用可能为肥胖的防治,尤其是儿童期肥胖提供新的思路和治疗策略。

关键词: 生物钟, 肥胖, 调控机制, 昼夜节律

CLC Number:

R723.14

YU Ting, LI Xiao-nan. Circadian clock and obesity[J]. journal1, 2018, 26(12): 1327-1331.

郁珽, 李晓南. 生物钟与肥胖[J]. 中国儿童保健杂志, 2018, 26(12): 1327-1331.

References

[1] Honma S.The mammalian circadian system:a hierarchical multi-oscillator structure for generating circadian rhythm[J].J Physiol Sci,2018,68(3):207-219.
[2] Dickmeis T, Weger BD, Weger M.The circadian clock and glucocorticoids-interactions across many time scales[J].Mol Cell Endocrinol,2013,380(1-2):2-15.
[3] 段晓楠,严双琴,汪素美,等.下丘脑-垂体-肾上腺整由昼夜节律指标随青春期发育变化的特征[J].中华流行病学杂志,2018,39(8):1086-1090.
[4] Chung S, Lee EJ, Cha HK, et al.Cooperative roles of the suprachiasmatic nucleus central clock and the adrenal clock in controlling circadian glucocorticoid rhythm[J].Sci Rep,2017,7:46404.
[5] Gamble KL, Berry R, Frank SJ, et al.Circadian clock control of endocrine factors[J].Nat Rev Endocrinol,2014,10(8):466-475.
[6] Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, et al.Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity[J].Faseb J,2016,30(9):3117-3123.
[7] Agil A, El-Hammadi M, Jimenez-Aranda A, et al.Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats[J].J Pineal Res,2015,59(1):70-79.
[8] Szewczyk-Golec K, Wozniak A, Reiter RJ.Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin:implications for obesity[J].J Pineal Res,2015,59(3):277-291.
[9] Carissimi A, Martins AC, Dresch F, et al.School start time influences melatonin and cortisol levels in children and adolescents-a community-based study[J].Chronobiol Int,2016,33(10):1400-1409.
[10] Kolbe I, Dumbell R, Oster H.Circadian clocks and the interaction between stress axis and adipose function[J].Int J Endocrinol,2015,2015:693204.
[11] Su Y, van der Spek R, Foppen E, et al.Effects of adrenalectomy on daily gene expression rhythms in the rat suprachiasmatic and paraventricular hypothalamic nuclei and in white adipose tissue[J].Chronobiol Int,2015,32(2):211-224.
[12] Boeke CE, Storfer-Isser A, Redline S, et al.Childhood sleep duration and quality in relation to leptin concentration in two cohort studies[J].Sleep,2014,37(3):613-620.
[13] Hart CN, Carskadon MA, Considine RV, et al.Changes in children′s sleep duration on food intake, weight, and leptin[J].Pediatrics,2013,132(6):e1473-480.
[14] Barnea M, Chapnik N, Genzer Y, et al.The circadian clock machinery controls adiponectin expression[J].Mol Cell Endocrinol,2015,399:284-287.
[15] Ribas-Latre A, Fekry B, Kwok C, et al.Rosiglitazone reverses high fat diet-induced changes in BMAL1 function in muscle, fat, and liver tissue in mice[J].Int J Obes,2018,Pt3:1.
[16] Honma K, Hikosaka M, Mochizuki K, et al.Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver[J].Metabolism,2016,65(4):482-491.
[17] Fonken LK, Nelson RJ.The effects of light at night on circadian clocks and metabolism[J].Endocr Rev,2014,35(4):648-670.
[18] Coomans CP, van den Berg SA, Houben T, et al.Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity[J].Faseb J,2013,27(4):1721-1732.
[19] Markwald RR, Melanson EL, Smith MR, et al.Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain[J].Proc Natl Acad Sci USA,2013,110(14):5695-5700.
[20] Fisher A, McDonald L, van Jaarsveld CH, et al.Sleep and energy intake in early childhood[J].Int J Obes (Lond),2014,38(7):926-929.
[21] Jarrin DC, McGrath JJ, Drake CL.Beyond sleep duration:distinct sleep dimensions are associated with obesity in children and adolescents[J].Int J Obes (Lond),2013,37(4):552-558.
[22] Vriend J, Reiter RJ.Melatonin feedback on clock genes:a theory involving the proteasome[J].J Pineal Res,2015,58(1):1-11.
[23] de Farias Tda S, de Oliveira AC, Andreotti S, et al.Pinealectomy interferes with the circadian clock genes expression in white adipose tissue[J].J Pineal Res,2015,58(3):251-261.
[24] Ferrell JM, Chiang JY.Circadian rhythms in liver metabolism and disease[J].Acta Pharm Sin B,2015,5(2):113-122.
[25] Silva-Nunes J, Oliveira A, Duarte L, et al.Factors related with adiponectinemia in obese and normal-weight women and with its variation in weight loss programs[J].Obes Facts,2013,6(2):124-133.
[26] Jamurtas AZ, Stavropoulos-Kalinoglou A, Koutsias S, et al.Adiponectin, resistin, and visfatin in childhood obesity and exercise[J].Pediatr Exerc Sci,2015,27(4):454-462.
[27] Hashinaga T, Wada N, Otabe S, et al.Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome[J].Endocr J,2013,60(4):483-492.
[28] Cheng T, Loy S, Toh J, et al.Predominantly nighttime feeding and weight outcomes in infants[J].Am J Clin Nutr,2016,104(2):380-388.
[29] Hatori M, Vollmers C, Zarrinpar A, et al.Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet[J].Cell Metab,2012,15(6):848-860.
[30] 宋沅瑾.睡眠对儿童饮食情况及身体活动水平影响的系列研究[D].上海:上海交通大学,2015.
[31] 徐艳芹, 吕春华, 詹海荣.儿童身体活动量以及屏幕时间与超重/肥胖相关性分析[J].山西医药杂志,2017,46(8):883-885.
[32] Shi S, Hida A, McGuinness OP, et al.Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2[J].Curr Biol,2010,20(4):316-321.
[33] Hirota T, Lee JW, St John PC, et al.Identification of small molecule activators of cryptochrome[J].Science,2012,337(6098):1094-1097.