Abstract: Objective To systematically review the findings of Chinese epidemiological studies in the past 16 years by a meta-analysis,to estimate the prevalence for autism spectrum disorder (ASD) in Chinese,and to extract its epidemiological characteristics as well as to further explore the differences of the prevalence of ASD between China and foreign countries. Method Databases such as Chinese Web of Knowledge,WeiPu,WanFang were searched for literatures published from January,2000 to December,2016 about the prevalence of ASD/autism in China. Results Totally thirty studies were included in meta-analysis.The prevalence of ASD was 26.50/10 000,and prevalence of autism was 14.00/10 000.There was a significant difference on the ASD prevalence among the following sub-factors including gender,age,screening criteria and so on except northern and southern China. Conclusions Although prevalence of ASD in Chinese children showed an increasing trend,it is still lower than that in foreign countries.The prevalence of ASD in China is clearly underestimated due to the limitation of the following influential factors,such as investigation population,monitoring methods,screening and diagnostic tools.

Key words: autism spectrum disorders, autism, prevalence, meta-analysis

摘要： 目的 采用Meta分析了解中国近16年孤独症谱系障碍(ASD)的患病率,掌握我国ASD的患病特征,进一步分析国内与国外ASD患病率存在差异的深层原因。方法 系统检索中国知网、维普、万方、Pubmed数据库2000年1月1日-2016年12月31日发表的中国儿童ASD患病情况的文献,采用R软件进行率值合并。结果 纳入30篇文献,中国儿童ASD患病率26.50/10 000;孤独症患病率为14.00/10 000。对发表年份、南北方等因素进行亚组分析,除南北方患病率间差异无统计学意义外,其余亚组患病率差异有统计学意义(P<0.05)。结论 尽管中国儿童ASD及孤独症患病率呈现递增趋势,但仍低于国外患病率报告;考虑限于调查人群、监测方法、筛查及诊断工具等因素影响,我国ASD患病率显然是被低估的。

关键词: 孤独症谱系障碍, 孤独症, 患病率, Meta分析