Abstract: Objective To explore hemoglobin level and its changes in premature infants under corrected age of 24 months,and to provide guidance on early detection for anemia in premature infants. Method Totally 461 eligible premature infants were offered early comprehensive intervention and regularly followed up. The hemoglobin content was measured at corrected age of 1,3,6,12 and 24 months. The changes of hemoglobin level in premature infants were analyzed by using the multilevel model. Results The average content of hemoglobin in premature infants was the lowest at corrected age of 1 month,and then increased with the infants getting older,and the average content of hemoglobin at corrected age of 10 months was the same as that in full-term infants. Multilevel model results showed that the average hemoglobin content of premature infants at corrected age of 1 month was 109.40 g/L,with instantaneous rate of change of 2.05 points,while the growth rate gradually decreased. The hemoglobin content at corrected age of 1 month was different among individuals,while the rate of growth of hemoglobin content did not find any differences between individuals. Gender,birth gestational age and birth weight were not found to have effect on the hemoglobin content at corrected age of 1 month in premature infants (P>0.05). Conclusions The initial value of hemoglobin in premature infants is different,but the rate of growth is the same. Early comprehensive intervention has positive effect on maintaining hemoglobin levels in premature infants. And the hemoglobin levels of premature infants should be monitored regularly.

Key words: premature infants, hemoglobin, follow-up study, early intervention, multilevel model

摘要： 目的 探讨早产儿矫正24月龄内血红蛋白水平及其变化规律,为早产儿贫血的早期发现提供指导。方法 对461例符合条件的早产儿进行定期随访,在早产儿矫正月龄1、3、6、12、24月检测其血红蛋白含量,利用多水平模型分析早产儿血红蛋白水平的变化规律。结果 早产儿血红蛋白水平在矫正1月龄时最低,之后随月龄增长呈上升趋势;接近矫正10月龄时与足月儿水平一致。多水平模型结果显示,矫正1~24月龄早产儿的血红蛋白含量平均初始值为109.40 g/L,初始增长速度为2.05,增长速度随月龄逐渐减慢;血红蛋白含量在矫正1月龄时存在个体间差异,但增长速度未发现个体间差异。结论 不同早产儿血红蛋白含量的初始水平不同,但其增长速度基本一致。早期干预对早产儿保持较好的血红蛋白水平具有重要意义。

关键词: 早产儿, 血红蛋白, 随访研究, 早期干预, 多水平模型