Abstract: Objective To evaluate the effect of probiotics supplementation on preventing children eczema systematically. Methods Randomized controlled trial studies regarding the effect of probiotics supplementation during pregnancy and early infancy on preventing children eczema since 2000 were analyzed by Meta-analysis with Rev Man 5.3 software.The fixed effect model or random effect model was selected by the heterogeneity test results.The RR value and 95%CI were calculated,publication bias was evaluated, and sensitivity analysis was conducted.Subgroup analysis was conducted according to different strains and different end time of follow-up. Results Totally 23 published articles were selected, including 3 004 intervention cases and 3 016 control cases.The RR and 95%CI of probiotics supplementation preventing children eczema was 0.76(95%CI:0.65~0.89) (P＜0.05);Subgroup analysis revealed that the RR and 95%CI of probiotic mixtures was 0.56(95%CI:0.41~0.78)(P＜0.05);The end time of follow-up for≤12 months and ≤24 months were 0.69(95%CI:0.51~0.93) (P＜0.05) and 0.77(95%CI:0.60~0.98) (P＜0.05), respectively. Conclusions In order to prevent children atopic eczema, probiotics supplementation during pregnancy and early infancy should be promoted.Moreover, probiotic mixtures with Lactobacillus and Bifidobacterium are the best choice.

Key words: probiotics, atopic eczema, randomized controlled trials, Meta-analysis

摘要： 目的 系统评价补充益生菌对儿童过敏性湿疹的预防效果。方法 运用Rev Man 5.3软件,对2000年以来国内外发表的有关益生菌预防儿童过敏性湿疹的随机对照试验研究进行Meta分析,根据异质性检验结果选择固定效应模型或随机效应模型,计算RR值及95%CI,评估发表偏倚,进行敏感性分析,并按干预菌株不同及随访时间点不同进行亚组分析。结果 最终纳入23篇文献,累计干预组3 004例,对照组3 016例。合并效应量结果显示,益生菌预防儿童过敏性湿疹的合并RR值为0.76(95%CI:0.65~0.89)(P＜0.05);亚组分析结果显示,使用混合菌株干预效果显著(RR＝0.56,95%CI:0.41~0.78)(P＜0.05),随访时间≤12个月及≤24个月所得结果表明益生菌预防儿童过敏性湿疹效果显著(P＜0.05),合并RR值分别为0.69(95%CI:0.51~0.93)和0.77(95%CI:0.60~0.98)。结论 应提倡孕期及婴幼儿期补充益生菌,推荐使用乳酸杆菌和双歧杆菌混合菌株,预防儿童过敏性湿疹。

关键词: 益生菌, 过敏性湿疹, 随机对照试验, Meta分析