Influencing factors of developmental regression in children with autism spectrum disorder

doi:10.11852/zgetbjzz2021-0483

Abstract

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized as heterogeneous clinical manifestations.Developmental regression, regarded as a specific subtype in ASD, is getting more and more attention.However, the influencing factors of regression are not clear.It is generally believed that it is a kind of developmental disorder caused by genetics, environment and their interaction.This review aims to summarize the influencing factors increasing risk of regressive autism from the perspective of environment and genetics, thereby providing references for the recognition and interventions in early childhood.

Key words: autism spectrum disorder(ASD), developmental regression, neurodevelopmental disorder

摘要： 孤独症谱系障碍(ASD)是一组以不同临床表现为主要特征的神经发育性障碍。近年来,ASD儿童的发育倒退(DR)受到越来越多的关注,并被认为可能是ASD的一种特殊亚型。目前关于ASD儿童DR的影响因素尚不清楚,综合文献分析主要是由遗传、环境及其交互作用共同引起。本文拟从遗传和环境两方面对目前报道的ASD儿童DR影响因素进行总结,为该部分ASD患儿的临床早期识别和干预提供参考。

关键词: 孤独症谱系障碍, 发育倒退, 神经发育性障碍

CLC Number:

R749.94

ZHOU Ping, CHEN Li. Influencing factors of developmental regression in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2022, 30(11): 1208-1211.

周平, 陈立. 孤独症谱系障碍儿童发育倒退的影响因素[J]. 中国儿童保健杂志, 2022, 30(11): 1208-1211.

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