Research progressin vitamin D and brain development

doi:10.11852/zgetbjzz2020-1036

Abstract

Abstract: In recent years, research on vitamin D has been progressing rapidly, and the relationship between vitamin D and brain development has received increasing attention. Vitamin D is a steroid hormone that can participate in the regulation of cell proliferation, differentiation and apoptosis. In addition to promoting calcium and phosphorus absorption, bone development and immune regulation, a large number of studies have shown that vitamin D can also affect nerves as a type of neurohormone for the development and function of the system. This article will focus on the vitamin D and vitamin D receptor (VDR) in the brain, the possible regulation of vitamin D on brain development, and the correlation between vitamin D and neuropsychiatric disorders in children.

Key words: vitamin D, vitamin D receptor, brain development

摘要： 近年来有关维生素D研究进展迅速,其中维生素D与大脑的发育之间的关系日益受到关注。维生素D是一种具有类固醇激素作用的物质,可参与调节细胞増殖、分化及凋亡,大量研究表明,维生素D除了具有促进钙磷吸收、骨骼发育及发挥免疫调节的作用,还可作为一类神经激素影响神经系统的发育和功能,本文将从大脑中的维生素D及维生素D受体、维生素D对脑发育可能的调控作用及维生素D与儿童神经精神障碍疾病的相关性等几方面进行阐述。

关键词: 维生素D, 维生素D受体, 脑发育

CLC Number:

R179

QIN Ying, YANG Shu-fen. Research progressin vitamin D and brain development[J]. Chinese Journal of Child Health Care, 2021, 29(4): 393-396.

秦莹, 仰曙芬. 维生素D与脑发育相关研究进展[J]. 中国儿童保健杂志, 2021, 29(4): 393-396.

References

[1] Wang TT,Tavera-Mendoza LE,Laparriere D,et al.Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D₃ target genes[J].Mol Endocrinol,2005,19(11):2685-2695.
[2] Ali A,Cui X,Eyles D.Developmental vitamin D deficiency and autism:putative pathogenic mechanisms[J].J Steroid Biochem Mol Biol,2018,175:108-118.
[3] /Lukaszyk E,Bień-Barkowska K,Bień B.Cognitive functioning of geriatric patients:is hypovitaminosis d the next marker of cognitive dysfunction and dementia[J].Nutrients,2018,10(8).DOI:10.3390/nu10081104.
[4] Cui X,Gooch H, Petty A,et al.Vitamin D and the brain:Genomic and non-genomic actions[J].Mol Cell Endocrinol, 2017,453:131-143.
[5] Balabanova S,Richter HP,Antoniadis G,et al.25-hydroxyvitamin D,24, 25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in human cerebrospinal fluid[J]. Klin Wochenschr 1984,62:1086-1090.
[6] El-Atifi M,Dreyfus M,Berger F,et al.Expression of CYP2R1 and VDR in human brain pericytes:the neurovascular vitamin D auto-crine/paracrine model[J].Neuroreport, 2015,26:245-248.
[7] Boontanrart M,Hall S D, Spanier J A,et al.Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism[J].J Neuroimmunol,2016, 292:126-136.
[8] Smolders J, Schuurman KG, van Strien ME,et al.Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue[J].J Neuropathol Exp Neurol,2013,72(2):91-105.
[9] Da FDA,Eyles D,Feron F.Vitamin D, a neuro-immunomodulator:implications for neurodegenerative and autoimmune diseases[J].Psychoneuro Endocrinology,2009,34(Suppl 1):265-277.
[10] Cui X, Pelekanos M, Liu PY,et al.The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain[J].Neuroscience,2013,236:77-87.
[11] Pertile RAN,Cui X,Hammond L,et al.Vitamin D regulation of GDNF/Ret signaling in dopaminer-gic neurons[J].FASEB J,2018,32(2):819-828.
[12] Pertile RAN,Cui X,Eyles DW.Vitamin D signalling and the differentiation of developing dopamine systems[J].Neuroscience,2016,333:193-203.
[13] Mácˇová L,Bicˇíková M,Ostatníková D,et al.Vitamin D,neurosteroid and autism[J].Physiol Res,2017,66(Suppl 3):333-340.
[14] Gooch H,Cui X,Anggono V,et al.1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex[J].Transl Psychiatry,2019,9(1):281 .
[15] Gezen-Ak D,Dursun E,Yilmazer S.Vitamin D inquiry in hippo-campal neurons:consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement[J].Neurol Sci,2013,34:1453-1458.
[16] Uberti F,Morsanuto V,Bardelli C,et al.Protective effects of 1α,25-Dihydroxyvitamin D3 on cultured neural cells exposed to catalytic iron[J]. Physiol Rep,2016,4.pii:e12769.
[17] Hur J,Lee PH,Kim MJ,et al.Regulatory effect of 25hydroxyvi-tamin D3 on nitric oxide production in activated microglia[J].Korean J Phsiol Pharmacol,2014,18:397-402.
[18] Huang Y,Ho Y,Lai C,et al.1,25-Dihydroxyvitamin D₃ attenuates endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation in primary cortical neuron-glia cultures[J].J Neuroinflammation,2015,12:147.
[19] Eyles DW,Trzaskowski M,Vinkhuyzen AAE,et al.The association between neonatal vitamin D status and risk of schizophrenia[J].Sci Rep,2018,8(1):17692.
[20] Schoenrock SA,Tarantino LM.Developmental vitamin D deficiency and schizophrenia:the role of animal models[J].Genes Brain Behav,2016,15:45-61.
[21] Berridge MJ.Vitamin D deficiency:infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia[J].Am J Physiol Cell Physiol,2018,314(2):C135-C151.
[22] Kang K,Huang XF,Wang Q,et al.Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study[J].Prog Neuropsychopharmacol Biol Psychiatry,2009,33:867-871.
[23] Steullet P,Cabungcal JH,Monin A,et al.Redox dysregulation, neuroinfl ammation, and NMDA receptor hypofunction:a “central hub” in schizophrenia pathophysiology[J].Schizophr Res,2016,176:41-51.
[24] Górny M, Wnuk A, Kamińska A,et al.Glutathione deficiency and alterations in the sulfur amino acid homeostasis during early postnatal development as potential triggering factors for schizophrenia-like behavior in adult rats[J].Molecules,2019, 24(23).doi:https://doi.org/10.3390/molecules 24234253
[25] Schoenrock SA,Tarantino LM.Developmental vitamin D deficiency and schizophrenia:the role of animal models[J].Genes Brain Behav,2016,15:45-61.
[26] Mazahery H,Camargo CA,Conlon C,et al.Vitamin D and autism spectrum disorder:a literature review[J].Nutrients,2016,218(4):236.
[27] Jia F,Shan L,Wang B,et al.Bench to bedside review:Possible role of vitamin D in autism spectrum disorder[J].Psychiatry Res,2018,260:360-365.
[28] Zhang ZY, Li SF, Yu LF, et al.Polymorphisms in vitamin D receptor genes in association with childhood autism spectrum disorder[J].Dis Markers,2018, 2018:1-7.
[29] Coşkun S, Şimşek Ş, Camkurt MA,et al.Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder[J].Gene,2016,588(2):109-114.
[30] Khoshbakht Y,Bidaki R,Salchi-abargouci A.Vitamin Dstatus and attention deficit hyperactivity disorder:a system-atic review and meta-analysis of observational studies[J].Adv Nutr,2018,9(1):9-20.
[31] Patrick RP,Ames BN.Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2:relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior[J].FASEB J,2015,29(6):2207-2222.
[32] Saedisomeolia A,Samadi M,Gholami F,et al.Vitamin D's molecular action mechanism in attention-deficit/ hyperactivity disorder:a review of evidence[J].CNS Neurol Disord Drug Targets,2018,17(4):280-290.
[33] Tang HL, Hua F, Wang J,et al.Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury[J].Brain Inj,2015,29(10):1165-1174.
[34] Elshorbagy HH, Barseem NF, Abdelghani WE, et al.Impact of vitamin D supplementation on sttention-deficit hyperactivity disorder in children[J].Ann Pharmacother,2018, 52(7):623-631.