Correlation between cognitive function and serum vitamin D level in children with benign epilepsy with centrotemporal spikes co-morbid with attention deficit hyperactivity disorder
- FANG Hai-bo, WANG Rong, CHU Lin-na, FENG Yan-fang, BAI Rong-rong, GUO Feng-tong
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Objective To analyze the correlation between cognitive function and serum vitamin D(VitD) level in children with benign epilepsy with centrotemporal spikes (BECT) co-morbid with attention deficit hyperactivity disorder (ADHD), in order to provide new ideas for the prevention and treatment of the cognitive impairment for these children. Methods Eighty BECT co-morbid with ADHD children who were first diagnosed from January 2020 to August 2021 were selected as the study subjects, meanwhile seventy children with the same age who underwent physical examination were enrolled into the control group. WISC-Ⅳ was used to evaluate the cognitive function of the children in two groups. Serum VitD level was detected by elecsys. Spearman correlation analysis was adopted between serum VitD level and the scores of WISC in the two groups. Results Compared with the control group, serum VitD overall level and VitD level of the subgroup with normal VitD level in children of BECT co-morbid with ADHD group were significantly lower (t=4.98, 8.56, P<0.05). In terms of WISC-Ⅳ assessment, the VCI,PRI,WMI,PSI and FSIQ scores of BECT co-morbid with ADHD group were significantly lower than those of control group(t=12.38, 17.84, 13.67, 11.20, 15.17, P<0.05). And the scores of VCI, PRI, WMI, PSI and FSIQ in the three subgroups of BECT co-morbid with ADHD group were significantly lower than those in the control group (t=9.28, 6.74, 5.37, 14.80, 7.67, 8.48, 11.64, 5.42, 6.40, 7.23, 8.16, 4.92, 11.50, 8.01, 6.41, P<0.05). Spearman correlation analysis showed that serum VitD level was positively correlated with VCI, PRI and FSIQ scores in children with BECT and co-morbid with ADHD (r=0.272, 0.276, 0.225, P<0.05), but not significantly correlated with WMI and PSI scores (r=0.154, 0.160, P>0.05). Conclusion Children with BECT and co-morbid with ADHD may have impaired cognitive function, and their serum VitD level is decreasing, which is correlated with the change of partial cognitive function.