Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (1): 59-63.DOI: 10.11852/zgetbjzz2023-0209

• Review • Previous Articles     Next Articles

Research progress in the relationship between vitamin D deficiency and central precocious puberty in children

LIU Xiaoqi1,2, WANG Kundi2, WANG Jun2, LI Zecheng3   

  1. 1. Beijng University of Chinese Medicine, Beijing 100029,China;
    2. Department of Pediatrics,China-Japan Friendship Hospital, Beijing 100029, China;
    3. China-Japan Friendship Institute of Clinical Medicine
  • Received:2023-03-05 Revised:2023-06-12 Online:2024-01-10 Published:2024-01-04
  • Contact: WANG Kundi, E-mail:


刘小琪1,2, 王琨蒂2, 王君2, 李泽铖3   

  1. 1.北京中医药大学,北京 100029;
    2.中日友好医院儿科, 北京 100029;
  • 通讯作者: 王琨蒂,
  • 作者简介:刘小琪(1996-),女,山西人,在读硕士研究生,主要研究方向为儿童内分泌疾病。

Abstract: Central precocious puberty (CPP) is an endocrine disease of children due to the early onset of hypothalamic-pituitary-gonadal axis function. This leads to increased secretion of gonadotropin release impulse, causing the development of internal and external genitalia and the presentation of secondary sex characteristics. Studies have found that the onset of CPP in children may be related to vitamin D deficiency. Vitamin D, affected by sunlight duration, acts on neurons and neurotransmitters in the hypothalamic-pituitary-gonadal axis, promotes obesity and affects the expression level of insulin-like growth factor-1, which are four factors involved in the occurrence and development of CPP. The overall effect of vitamin D combined with gonadotropin-releasing hormone analogues on CPP is significant. This article reviews the correlation between vitamin D deficiency and CPP, as well as the possible mechanism of action, in order to provide some theoretical basis for researchers.

Key words: vitamin D, central precocious puberty, child

摘要: 中枢性性早熟(CPP)是由于下丘脑-垂体-性腺轴功能提前启动,导致促性腺激素释放激素脉冲分泌增强,使内外生殖器发育和第二性征呈现的儿童内分泌疾病。研究发现维生素D缺乏可能与CPP的发病有关,维生素D可能会受到日照时间的影响、作用下丘脑-垂体-性腺轴上的神经元及神经递质、促进肥胖形成、影响胰岛素样生长因子-1的表达水平这4个因素参与CPP的发生发展,维生素D联合促性腺激素释放激素类似物治疗CPP的总体效果显著。本文就维生素D缺乏与CPP的相关性以及可能的作用机制做一综述,以期为研究者提供一定的理论依据。

关键词: 维生素D, 中枢性性早熟, 儿童

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