Effects of metformin therapy on obese children in their different glucose metabolism status
LIU Xiu-qin1,GONG Chun-xiu2,CAO Bing-yan2,HUANG Hui2,DONG Qian2,XIE Ruo-xiang2
1 Beijing Haidian Maternal and Children Health Care Hospital,Beijing 100061,China; 2 Beijing Children's Hospital ,Capital Medical University, Beijing 100045,China
LIU Xiu-qin,GONG Chun-xiu,CAO Bing-yan,HUANG Hui,DONG Qian,XIE Ruo-xiang. Effects of metformin therapy on obese children in their different glucose metabolism status[J]. journal1, 2011, 19(11): 1024-1027.
[1] Pontiroli AE.Type 2 diabetes mellitus is becoming the most common type of diabetes in school children[J]. Acta diabetol,2004,41(3):85-90. [2] 中国肥胖问题工作组.中国学龄儿童青少年超重、肥胖筛查体重指数分类标准[J].中华流行病学杂志,2004,25(2):97-102. [3] 邓尚平.临床糖尿病学[M].成都:四川科学技术出版社, 2000: 62-64. [4] The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus:Follow-up report on the diagnosis of diabetes mellitus[J].Diabetes Care,2003,26:3160-3167. [5] Craig ME,Hattersley A, Donaghue KC.Definition,epidemiologyand classification of diabetes in children and adolescents[J].Pediatr Diabetes,2009, 10(S12):3 -12. [6] Amed S, Daneman D, Mahmud FH,et al.Type 2 diabetes in children and adolescents[J].Expert Rev Cardiovasc Ther,2010,8:393- 406. [7] Freemark M,Bursey D.The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes[J].Pediatrics,2001,107:1-7. [8] Geoffrey R,Louise A,Sarah PGM.Cowell randomized,controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin[J].Journal of clinical endocrino Lgy & Metabolism, 2006,91(6):2074-2080.