Abstract: 【Objective】 To investigate the reference values of serum cystatin C within the healthy preschool children. 【Method】 The automatic biochemical analyzer(OLYMPUS AU2700)was used to detect the level of serum cystatin C of 474 healthy preschool children and 172 normal adults.Then the data were analyzed with statistical methods. 【Results】 The value of cystatin C of infant group, child care group,preschool group and normal adult group were 0.62~1.74,0.47~1.15,0.41~0.97 mg/L and 0.46~1.02 mg/L,respectively.Infant group,child care group and normal adult group reference values were significantly different (P<0.05).There was no difference between preschool group and normal adult group.Each of the groups were compared by sex,between boys and girls within each group of Cys C reference values were not significantly different (P>0.05).Normal adult reference range for the control group,infant group,child care group overrun detection rates were 56.8%,11.1%. 【Conclusions】 Infant group, child care group and adult group can adopt different reference values of serum cystatin C,preschool group and normal adult group can use the same.There is no difference between boys and girls for serum cystatin C.

Key words: cystatin C, pre-school children, reference value

摘要： 【目的】 通过检测学龄前儿童的血清胱抑素C, 旨在建立不同时期学龄前儿童的正常参考值范围, 为临床医生提供有意义的数据参考。 【方法】 应用全自动生化分析仪检测学龄前儿童474例和正常成人172例空腹血清胱抑素C。 【结果】 婴儿组、幼儿组、学龄前组及正常成人组Cys C正常值范围分别为0.62~1.74、0.47~1.15、0.41~0.97 mg/L和0.46~1.02 mg/L;各组与正常成人组比较发现, 婴儿组、幼儿组与正常成人组参考值差异有统计学意义(P<0.05),学龄前组与正常成人组参考值差异无统计学意义(P>0.05);将各组按性别分别比较,各组内男女间Cys C参考值差异均无统计学意义(P>0.05);以正常成人组参考值范围为对照,婴儿组、幼儿组超限检出率分别为56.8%、11.1%。 【结论】 婴儿组、幼儿组儿童可与成人采用不同的Cys C参考值范围,学龄前组可与成人采用相同的Cys C参考值范围,且参考值范围与性别无关。

关键词: 胱抑素C, 学龄前儿童, 正常参考范围