Abstract: Objective To explore the relationship between the serum leptin (LP) and development degree for obese children. Methods Height was measured with horizontal height analyzer.Serum LP was measured by ELISA,and t-test,Kruskal-Wallis H test,the rank conversion SNK test,the Spearman's rank correlation were used to analyze the data. Results 238 healthy children were inspected (male 121 cases,117 cases),152 cases in the normal group,61 cases in overweight group,25 cases in the obesity group;There had significant statistical difference in LP among the three groups(P<0.05);There had a positive correlation between serum LP and BMI(r_s=0.718,P<0.05);There had significant statistical differences in BMI among the three groups(P<0.05);There had no significant statistical difference in BMI between male and female in three groups(P>0.05). Conclusions With BMI increasing,serum LP is rising,a positive correlation between them indicates that obesity children may exist LP resistance.

Key words: leptin, body mass index, obesity, children

摘要： 目的 研究超重肥胖幼儿瘦素(leptin,LP)水平与体质指数(body mass index,BMI)的关系。方法 采用卧式身高仪测量儿童身高,电子秤称量体重。利用酶联免疫吸附法(ELISA)测定血清LP水平。采用t检验、Kruskal-Wallis H检验、秩转换的方差分析、Spearman秩相关分析统计数据。结果 共检查238例(男121例,女117例)健康幼儿,正常组152例,超重组61例,肥胖组25例;三组间血清LP水平比较差异均有统计学意义(P<0.05);幼儿血清LP水平与体质指数(body mass index,BMI)之间有正相关性(r_s=0.718,P<0.05);三组间BMI比较差异有统计学意义(P<0.05);三组内男、女童BMI之间比较,差异均无统计学意义(P>0.05)。 结论 随着BMI增加,血清LP水平呈上升趋势,二者之间存在正相关,表明肥胖幼儿可能存在LP抵抗。

关键词: 瘦素, 体质指数, 肥胖, 幼儿