Abstract: Objective To apply a Meta-analysis of various studies from different ethnic populations and assess the association of the melanocortin 4 receptor(MC4R) polymorphism with childhood obesity. Methods All published literature were retrieved that investigated association of MC4R variants with obesity from PubMed,CNKI and Wanfang database.Pooled odds ratio (OR) with 95% confidence interval (CI) and weighted mean difference (WMD) were calculated using fixed- or random-effects model. Results A total of 12 case-control studies were eligible for this analysis.Meta-analysis showed that MC4R rs17782313 increased the risk of childhood obesity in all models (CC vs TT,OR=1.84,95%CI:1.44~2.36;CC vs CT,OR=1.48,95%CI:1.29~1.70,P_het=0.756;CC vs TT/TC,OR=1.67,95%CI:1.39~1.99;TC/CC vs TT,OR=1.35,95%CI:1.19~1.55).Moreover,the association between genotypes and childhood the body mass index (BMI) Z-score was also significant (WMD=0.14,95%CI:0.06~0.23,CC vs TT). Conclusion The present meta-analysis confirms the association of MC4R polymorphism with risk of childhood obesity.

Key words: melanocortin 4 receptor, polymorphism, children, obesity, Meta-analysis

摘要： 目的 应用Meta分析系统评价黑色素皮质激素第四受体基因(melanocortin-4 receptor gene,MC4R) rs17782313与儿童肥胖易感性的关系,以得到更有说服力的结论。方法 利用计算机检索数据库PubMed,中国知网、万方等,手工检索纳入文献的参考文献。采用STATA 11.0软件进行Meta分析。利用随机效应模型或固定效应模型计算其合并比值比(OR)和95%可信区间(95%CI),以及合并加权均数差(WMD)的值。结果 共有12个研究纳入研究,其中在纯合子模型(OR=1.84,95%CI:1.44~2.36,P_het=0.001)、杂合子模型(OR=1.48,95%CI:1.29~1.70,P_het=0.756)、显性模型(OR=1.67,95%CI:1.39~1.99,P_het=0.082)和隐性模型(OR=1.35,95%CI:1.19~1.55,P_het=0.000),差异均有统计学意义。在基因型与体质指数(body mass index,BMI)Z-score定量关联性分析中,发现rs17782313T>C的突变会影响儿童的BMI Z-score(WMD=0.14,95%CI:0.06~0.23,CC vs TT)。结论 Meta分析研究结果证实了MC4R rs17782313与儿童肥胖的关系。

关键词: MCR4, 基因多态性, 儿童, 肥胖, Meta分析