Abstract: Objective To explore the early diagnostic value of brainstem auditory evoked potential(BAEP) and magnetic resonance imaging(MRI) in the neonates with bilirubin encephalopathy. Methods Retrospective analysis of the relared clinical indicators in 137 neonates with hyperbilirubinemia. Results The levels of serum total bilirubin,serum total bilirubin/albumin were higher in the neonates with abnormal BAEP,abnormal MRI and acute bilirubin encephalopathy than those with normal BAEP,normal MRI and without cute bilirubin encephalopathy (P<0.05).Abnormal rate of BAEP was positively correlated to that of MRI (r=0.466,P<0.05).On the diagnosis of bilirubin encephalopathy,the sensitivity of BAEP(87.18%) was higher than MRI (64.10%),but the specificity of BAEP(78.57%) was lower than MRI(93.88%). Conclusion BAEP and MRI examinations have important clinical value in the early diagnosis of bilirubin encephalopathy in the neonates.

Key words: hyperbilirubinemia, bilirubin encephalopathy, brainstem auditory evoked potential, magnetic resonance imaging

摘要： 目的 研究脑干听觉诱发电位(BAEP)和磁共振(MRI)两种检查手段在新生儿高胆红素脑病早期诊断中的价值。方法 回顾性分析137例高胆红素血症患儿临床相关指标。结果 BAEP、MRI异常和有急性胆红素脑病症状组血清总胆红素、血清总胆红素/白蛋白值明显高于BAEP、MRI正常组和无急性胆红素脑病组(P<0.05)。BAEP与MRI异常率呈正相关(r=0.466,P<0.05)。BAEP诊断胆红素脑病的敏感性(87.18%)高于MRI(64.10%),但特异性(78.57%)低于MRI(93.88%)。结论 BAEP和MRI检查在新生儿高胆红素脑病早期诊断中有重要意义。

关键词: 高胆红素血症, 胆红素脑病, 脑干听觉诱发电位, 磁共振成像