Abstract: Objective To investigate the serum uric acid level and its distribution in children aged 3~6 years in urban Tianjin,and to explore the reference range of serum uric acid for healthy pre-school children. Methods 26 kindergartens involving 4 083 children aged 3~6 years were randomly selected from the urban Tianjin.Serum uric acid was tested using the peripheral blood from right leech-finger. Results 1)The average level of serum uric acid was (243.0±52.8) μmol/L.There were significant differences of serum uric acid level between sex,age and body mass index(BMI).Serum uric acid levels boys,children aged 5~6 years old,and children with obesity/overweight had higher serum uric acid levels than girls,children aged 3~4 years,and children with normal weight,respectively.2)Normal weight and overweight children were selected to develop the reference range for healthy children,stratified by age and sex.The reference ranges of serum uric acid level are (240.8±101.1)μmol/L for 3~4 years old boys,(236.0±105.4) μmol/L for 3~4 years old girls,(244.1±101.4) μmol/L for 5~6 years old boys,and (236.5±98.6) μmol/L for 5~6 years old girls,respectively. Conclusion sSex,age and BMI may affect children's serum uric acid level.Reference range of serum uric acid for healthy children by different age and sex would give suggestions for clinical practice.

Key words: uric acid, reference range, children

摘要： 目的 了解天津市城市地区3~6岁儿童血尿酸水平及分布特征,探讨其正常参考值范围。方法 随机抽取天津市城市地区26所幼儿园4 083名3~6岁儿童,采集末梢血,检测血浆尿酸水平。结果 1)血尿酸水平为(243.0±52.8) μmol/L,男童尿酸水平高于女童(t=5.423,P<0.001);5~6岁组高于3~4岁组(t=-2.245,P=0.025);肥胖组儿童血尿酸水平高于超重组及体型正常组(F=58.641,P<0.001)。2)选择体型正常和超重儿童为“健康人群”,根据不同年龄、性别分别计算尿酸正常值,3~4岁组男童(240.8±101.1) μmol/L,女童(235.2±105.8) μmol/L,5~6岁组男童(244.1±101.4) μmol/L,女童(236.5±98.6) μmol/L。结论 性别、年龄、体型是影响城市地区3~6岁儿童尿酸水平的重要因素。根据不同性别及年龄建立的城市地区3~6岁儿童血尿酸水平弥补了当前缺乏相应标准的不足。

关键词: 尿酸, 参考值范围, 儿童