Abstract: Objective To explore the expression and clinical significance of 1,25-(OH)D₃ and IgE in wheezing infants and young children. Methods Children with recurrent wheezing children had been randomly enrolled from September 2015 to March 2016 in our hospital.According to the asthma predictive index,they were divided into 2 groups:wheezing group Ⅰ with positive predictive index(n=29)and wheezing group Ⅱ with negative predictive index(n=23).The healthy children had been enrolled randomly as normal control group(n=23).The serum level of 1,25-(OH)D₃ and the IgE was measured. Results The serum levels of 1,25-(OH)D₃ in wheezing groups were lower than those of normal control group,the levels of 1,25-(OH)D₃ in group Ⅰ were lower than the group Ⅱ,the difference was statistically significant (P<0.05);The level of IgE in wheezing groupⅠwas significantly higher than those in wheezing group Ⅱand the control group (P<0.05),while wheezing group Ⅱ group and the control group had no significant difference (P>0.05);There was remarkably negative correlation between vitamin D and IgE in group Ⅰ(r=-0.915,P<0.01). Conclusion The level of 1,25-(OH)D₃ is significantly decline in recurrent wheezing children with atopic,and there is remarkably negative correlation between the serum levels of 1,25-(OH)D₃ and IgE in wheeze children with atopic.

Key words: wheezing, 1,25-(OH)D₃, child

摘要： 目的 研究血清1,25-(OH)D₃水平和总IgE水平在喘息婴幼儿中的表达及临床意义。方法 随机选取2015年9月-2016年3月于本院住院的喘息患儿52例,依据哮喘预测指数分为哮喘预测指数阳性的喘息Ⅰ组(n=29)和哮喘预测指数阴性的喘息Ⅱ组(n=23),对照组为本院门诊健康体检儿童(n=23)。分别测定3组患儿血清1,25-(OH)D₃和总IgE水平。结果 喘息Ⅰ组和喘息Ⅱ组患儿血清1,25-(OH)D₃水平均低于对照组,差异有统计学意义(P<0.05),喘息Ⅰ组1,25-(OH)D₃水平低于喘息Ⅱ组(P<0.05),喘息Ⅰ组IgE水平高于喘息Ⅱ组和对照组,差异有统计学意义(P<0.05),喘息Ⅱ组和对照组之间差异无统计学意义(P>0.05);喘息Ⅰ组血清1,25-(OH)D₃与IgE呈负相关性(r=-0.915,P<0.01)。结论 1,25-(OH)D₃水平在有特应质的反复喘息儿童中显著降低,并且与总IgE水平呈负相关。

关键词: 喘息, 1,25-(OH)D₃, 婴幼儿