Abstract: Objective To observe the levels of FEV₁,FVC and FEV₁/FVC in children with asthma,and to analyze the correlation with cytokines and immune function. Methods A total of 100 children with asthma who were treated in the First People's Hospital of Huaian City from August 2015 to August 2018 were enrolled as asthma group,and 100 non-asthmatic children at the same period were selected as control group.The levels of FEV₁,FVC,FEV₁/FVC,cytokines and immune function of the two groups were tested,and the correlation among the levels of FEV₁,FVC,FEV₁/FVC,cytokines and immune function were analyzed. Results The levels of FEV₁,FVC,FEV₁/FVC,CD3+,CD4+ and CD8+ in asthma group were 78.47±2.13,80.23±2.76,75.68±1.05,61.09±2.43,43.15±3.0 and 21.83±2.27,respectively,significantly lower than those in control group(t=-40.376,-37.674,-56.508,-11.175,-14.530,-34.348,P<0.001).However,the levels of IL-4,IL-5 and IL-13 in asthma group were 156.63±10.14,55.26±3.45 and 57.54±4.16,respectively,which were significantly higher than those in control group(P<0.05).The levels of FEV₁,FVC and FEV₁/FVC in asthmatic children were negatively correlated with the levels of cytokines(IL-4,IL-5 and IL-13)(r=-0.552--0.358),positively related to the indexes of immune function(r=0.398—0.514). Conclusion The levels of FEV₁,FVC and FEV₁/FVC in asthmatic children are low,and closely related to cytokines and immune function.

Key words: asthma, lung function, cytokines, immune function

摘要： 目的 观察哮喘患儿第1秒用力呼气量(FEV₁)、用力肺活量(FVC)、FEV₁/FVC水平,并分析其与细胞因子和免疫功能的相关性。方法 选取2015年8月-2018年8月在淮安市第一人民医院接受治疗的100例哮喘患儿为哮喘组,同时选取同期在本院接受体检的100例非哮喘患儿为对照组。观察两组患儿FEV₁、FVC、FEV₁/FVC水平、细胞因子和免疫功能的差异,分析哮喘患儿FEV₁、FVC、FEV₁/FVC水平、细胞因子和免疫功能的相关性。结果 哮喘组患儿的FEV₁、FVC、FEV₁/FVC、CD3+、CD4+、CD8+水平分别为78.47±2.13、80.23±2.76、75.68±1.05,61.09±2.43、43.15±3.02、21.83±2.27,低于对照组(t=-40.376、-37.674、-56.508、-11.175、-14.530、-34.348,P<0.001);哮喘组患儿的IL-4、IL-5、IL-13水平分别为156.63±10.14、55.26±3.45、57.54±4.16,高于对照组(t=69.519、61.958、64.306,P<0.05);哮喘患儿的FEV₁、FVC、FEV₁/FVC水平与细胞因子(IL-4、IL-5、IL-13)水平呈负相关(r=-0.552~-0.358),与免疫功能指标(CD3+,CD4+,CD8+)呈正相关(r=0.398~0.514)。结论 哮喘患儿FEV₁、FVC、FEV₁/FVC水平较低,且与细胞因子和免疫功能密切相关。

关键词: 哮喘, 肺功能, 细胞因子, 免疫功能