Progress on the mechanism of intrauterine growth restriction affecting cognitive development

doi:10.11852/zgetbjzz2018-0672

Abstract

Abstract: Intrauterine growth restriction(IUGR) refers to the fact that fetal development in the uterus does not reach its growth potential due to genetic or environmental factors. IUGR is not only associated with peripartum asphyxia,hypothermia,hypoglycemia and other diseases,but also can affect the long-term development of the nervous system,resulting in cognitive developmental disorders,behavioral problems. This article reviews the mechanism that IUGR may impair cognitive development in terms of fetal circulatory redistribution,brain volume and structure,brain metabolism,and epigenetic inheritance,in order to provide basis for revealing and intervening cognitive impairment caused by IUGR.

Key words: intrauterine growth restriction, cognition, mechanism

摘要： 胎儿宫内生长受限(IUGR)是指由于遗传或环境因素,胎儿在宫内的发育未达到其生长潜能。IUGR不仅与围生期窒息、低体温、低血糖等疾病相关,也可影响远期的神经系统发育,造成认知发育障碍、行为问题等。本文从胎儿循坏再分配、大脑容量及结构、大脑代谢、表观遗传四个方面综述了IUGR可能损害认知发育的机制,为揭示和干预IUGR导致的认知障碍提供依据。

关键词: 宫内生长受限, 认知, 机制

CLC Number:

R179

LIU Wen-jing,YUAN Zhao-hong. Progress on the mechanism of intrauterine growth restriction affecting cognitive development[J]. journal1, 2019, 27(3): 281-284.

刘文晶,袁兆红. 宫内生长受限影响认知发育的机制研究进展[J]. 中国儿童保健杂志, 2019, 27(3): 281-284.

References

[1] Hunter DS,Hazel SJ,Kind KL,et al.Programming the brain:common outcomes and gaps in knowledge from animal studies of IUGR[J].Physiol Behav,2016,164:233-248.
[2] Liu J,Wang X,Wang Y,et al.The incidence rate,high-risk factors,and short- and long-term adverse outcomes of fetal growth restriction[J].Medicine,2014,93(27):e210.
[3] McCowan LM,Figueras F,Anderson NH.Evidence-based national guidelines for the management of suspected fetal growth restriction:comparison,consensus,and controversy[J].Am J Obstet Gynecol,2018,218(Suppl 2):855-868.
[4] Korzeniewski SJ,Allred EN,Joseph RM,et al.Neurodevelopment at age 10 years of children born <28 weeks with fetal growth restriction[J].Pediatrics,2017,140(5):pii:e20170697.
[5] Margerison-Zilko C.The contribution of maternal birth cohort to term small for gestational age in the United States 1989-2010:an age,period,and cohort analysis[J].Paediatr Perinat Epidemiol,2014,28(4):312-321.
[6] Wixey JA,Chand KK,Colditz PB,et al.Review:neuroinflammation in intrauterine growth restriction[J].Placenta,2017,54:117-124.
[7] Oros D,Altermir I,Elia N,et al.Pathways of neuronal and cognitive development in children born small-for-gestational age or late preterm[J].Ultrasound Obst Gyn,2014,43(1):41-47.
[8] Sharma D,Farahbakhsh N,Shastri S,et al.Intrauterine growth restriction-part 2[J].J Matern-Fetal Neo M,2016,29(24):4037-4048.
[9] Murray E,Fernandes M,Fazel M,et al.Differential effect of intrauterine growth restriction on childhood neurodevelopment:a systematic review[J].BJOG-Int J Obstet Gy,2015,122(8):1062-1072.
[10] Chen J,Chen P,Bo T,et al.Cognitive and behavioral outcomes of intrauterine growth restriction school-age children[J].Pediatrics,2016,137(4):pii:20153865.
[11] Rogne T,Jacobsen GW,Skranes J,et al.Fetal growth,cognitive function,and brain volumes in childhood and adolescence.[J].Obstet Gynecol,2015,125(3):673-682.
[12] Devore GR.The importance of the cerebroplacental ratio in the evaluation of fetal well-being in SGA and AGA fetuses.[J].Am J Obstet Gynecol,2015,213(1):5-15.
[13] Bellido-González M,Díaz-López M,López-Criado S,et al.Cognitive functioning and academic achievement in children aged 6-8 years,born at term after intrauterine growth restriction and fetal cerebral redistribution[J].J Pediatr Psychol,2016:w60.
[14] Tolsa CB,Zimine S,Warfield SK,et al.Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction[J].Pediatr Res,2004,56(1):132-138.
[15] Padilla N,Falcón C,Sanz-Cortés M,et al.Differential effects of intrauterine growth restriction on brain structure and development in preterm infants:A magnetic resonance imaging study[J].Brain Res,2011,1382(9):98-108.
[16] Polat A,Barlow S,Ber R,et al.Volumetric MRI study of the intrauterine growth restriction fetal brain[J].Eur Radiol,2017,27(5):2110-2118.
[17] Benavides-Serralde A,Hernández-Andrade E,Fernández-Delgado J,et al.Three-dimensional sonographic calculation of the volume of intracranial structures in growth-restricted and appropriate-for-gestational age fetuses[J].Ultrasound Obst Gyn,2009,33(5):530-537.
[18] Uno H,Lohmiller L,Thieme C,et al.Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques.I.Hippocampus[J].Dev Brain Res,1990,53(2):157-167.
[19] Dieni S,Rees S.Dendritic morphology is altered in hippocampal neurons following prenatal compromise[J].Dev Neurobiol,2003,55(1):41-52.
[20] Ash JA,Velazquez R,Kelley CM,et al.Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice[J].Neurobiol Dis,2014,70(5):32-42.
[21] Liu J,Liu L,Chen H.Antenatal taurine supplementation for improving brain ultrastructure in fetal rats with intrauterine growth restriction[J].Neuroscience,2011,181:265-270.
[22] Sang-Sun L,Tanaka HT.Brain metabolism in fetal intrauterine growth restriction:a proton magnetic resonance spectroscopy study[J].Am J Obstet Gynecol,2011,205(5):1-8.
[23] Simes RV,Muoz-Moreno E,Cruz-Lemini M,et al.Brain metabolite alterations in infants born preterm with intrauterine growth restriction:association with structural changes and neurodevelopmental outcome[J].Am J Obstet Gynecol,2017,216(1):61-62.
[24] Vliet EV,Eixarch E,Illa M,et al.Metabolomics Reveals Metabolic Alterations by Intrauterine Growth Restriction in the Fetal Rabbit Brain[J].Plos One,2013,8(5):e64545.
[25] O'Grady SP,Caprau D,Ke X,et al.Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants[J].Syst Biol Reprod Med,2010,56(4):292-302.
[26] Numpang B,Ke X,Yu X,et al.Fetal growth restriction alters hippocampal 17-beta estradiol and estrogen receptor alpha levels in the newborn male rat[J].Syst Biol Reprod Med,2013,59(4):184-190.
[27] Fung C,Ke X,Brown AS,et al.Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression[J].Pediatr Res,2012,72(1):2-9.
[28] Ding Y,Cui H.Integrated analysis of genome-wide DNA methylation and gene expression data provide a regulatory network in intrauterine growth restriction[J].Life Sci,2017,179:60-65.
[29] Molinaro P,Cataldi M,Cuomo O,et al.Genetically modified mice as a strategy to unravel the role played by the Na⁺/Ca²⁺ exchanger in brain ischemia and in spatial learning and memory deficits[J].Oxygen Transport to Tissue XXXIII,2013,961(2):213-222.
[30] Balboula AZ,Stein P,Schultz RM,et al.Knockdown of RBBP7 unveils a requirement of histone deacetylation for CPC function in mouse oocytes[J].Cell Cycle,2014,13(4):600-611.
[31] 陆静毅,贾伟平.胎儿宫内生长受限与表观遗传修饰[J].上海医学,2010,33(12):1150-1152.
[32] Ke X,McKnight RA,Caprau D,et al.Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics[J].Physiol Genomics,2011,43(20):1160-1169.