Abstract: Objective To investigate the levels of vitamin A,D and E of neonates in hospital and the related influencing factors in Anyang,so as to provide scientific evidence for the prevention of vitamin A,D and E deficiency. Methods A total of 329 neonates treated in the Pediatrics Department of the People′s Hospital of Anyang City were enrolled in this study from May 2017 to February 2019.High performance liquid chromatography(HPLC) and liquid chromatography tandem mass spectrometry (MS/MS) were used to test the levels of vitamin A,D,E of neonates.The influencing factors for the levels of vitamin A,D,E were analyzed. Results 1) The levels of vitamin A,D,E in newborns were (0.17±0.09) mg/L,(14.21±12.05)ng/ml and (6.50±3.80)mg/L,respectively.2) Significant differences were found on vitamin A level between preterm infants and full-term infants,vitamin D level between boys and girls,vitamin E level between high-risk and non-high-risk infants (P<0.05).But there were no significant differences on vitamin A、D、E levels among children in different weight groups (P>0.05).3) Vitamin A subclinical deficiency,vitamin D and vitamin E deficiency accounted for a higher proportion.4) There were significant differences on vitamin D levels among neonates born in different seasons and in neonates between vitamin D supplementation ≥400 U/d and ＜ 400 U/d at the end of three months of pregnancy (P<0.05). Conclusionss Most neonates in hospital in Anyang area have vitamin A,D and E deficiency.Preterm and high-risk infants may be related to neonatal vitamin A and E levels,respectively.Different sex,seasons and vitamin D supplementation dose at the end of pregnancy are correlated with vitamin D level in neonates.

Key words: vitamin A, vitamin D, vitamin E, newborn

摘要： 目的 调查河南安阳地区住院治疗中新生儿维生素A、D、E水平及相关影响因素,为早期防治维生素A、D、E缺乏提供科学依据。方法 选取2017年5月-2019年2月在安阳市人民医院新生儿科住院治疗的329例新生儿为研究对象。采用高效液相色谱法和液相串联质谱法检测新生儿维生素A、D、E。结果 1)新生儿维生素A水平为(0.17±0.09) mg/L,维生素D水平为(14.21±12.05) ng/ml,维生素E水平为(6.50±3.80) mg/L。2) 足月儿与早产儿的维生素A水平,不同性别新生儿的维生素D水平,高危儿与非高危儿的维生素E水平差异均有统计学意义(P＜0.05)。不同体重组维生素A、D、E水平差异无统计学意义(P＞0.05)。3) 维生素A亚临床缺乏,维生素D及维生素E缺乏比例较高。4) 不同季节出生的新生儿维生素D水平差异有统计学意义(P＜0.05)。孕末期3个月补充维生素D剂量≥400 U/d与＜400 U/d的新生儿维生素D水平差异有统计学意义(P＜0.05)。结论 河南安阳地区住院治疗中新生儿大部分存在维生素A、D、E缺乏,是否足月、是否为高危儿可能分别与维生素A、E水平有关。不同性别、季节及孕末期补充维生素D的剂量与维生素D水平有关。

关键词: 维生素A, 维生素 D, 维生素E, 新生儿