Assessment of bisphenol A exposure and influencing factors among two-year-old children living in a county of Jiangsu province

Abstract

Abstract: Objective To evaluate levels of urinary bisphenol A,daily intake and its influencing factors among two-year-old children. Methods Questionnaires and spot urine samples were collected from 365 children living in a county of Jiangsu province.Urinary BPA concentration was determined,daily intake was calculated and the influencing factors were identified. Results The detection rate of urinary BPA was 72.05%.The detectable range was 0.20~106.38 μg/L.The median value and the median value of BPA concentration with creatinine correction were 0.95 μg/L and 2.96 μg/g,respectively.The calculated maximum value of BPA daily intake was 4.596 μg/kg bw/24 h and was lower than the tolerable daily intake(TDI)in Europe.Statistical analysis indicated that the BPA concentrations were similar between female and male children.The locations of residence had statistically significant effects on concentrations (P<0.05). Conclusion The findings suggests that the two-year-old children are widely exposed to BPA in the studied county and the calculated daily intakes are lower than TDI in Europe.

Key words: bisphenol A, urine, two-year-old children, daily intake calculation

摘要： 目的评估2岁幼儿尿中双酚A(bisphenol A，BPA)水平和每日摄入量及其影响因素，为进一步研究BPA对幼儿健康影响提供基础数据。方法选取某县365名幼儿，由其父母完成问卷调查并协助幼儿采集尿样，测定尿中BPA含量，估算每日摄入量及分析影响因素。结果 BPA检出率为72.05%，可检出浓度范围为0.20～106.38 μg/L，肌酐未校正和校正后中位值分别为0.95 μg/L和2.96 μg/g。每日摄入量按肌酐估算最大值为4.596 μg/kg bw/24 h，低于欧盟食品安全机构(European Food Safety Authority，EFSA)提出的BPA每日允许摄入量(tolerable daily intake，TDI)。统计分析结果显示不同性别幼儿BPA水平相似，而不同居住地间BPA水平差异有统计学意义(P<0.05)。结论该地区2岁幼儿普遍暴露于BPA，暴露水平低于EFSA提出的TDI。

关键词: 双酚A, 尿, 2岁幼儿, 每日摄入量估算

CLC Number:

R126

LV Shen-liang,WU Chun-hua,LIU Ping,ZHANG Ji-ming,CHANG Xiu-li,ZHOU Zhi-jun. Assessment of bisphenol A exposure and influencing factors among two-year-old children living in a county of Jiangsu province[J]. journal1, 2014, 22(10): 1014-1017.

吕沈亮，邬春华，刘萍，张济明，常秀丽，周志俊. 江苏省某县两岁幼儿双酚A暴露水平评估及影响因素分析[J]. 中国儿童保健杂志, 2014, 22(10): 1014-1017.

References

[1] Shelby MD.NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A[J].Ntp Cerhr Mon,2008,22:1-64.
[2] Li X,Ying GG,Su HC,et al.Simultaneous determination and assessment of 4-nonylphenol,bisphenol A and triclosan in tap water,bottled water and baby bottles[J].Environ Int,2010,36(6):557-562.
[3] Groff T.Bisphenol A:invisible pollution[J].Curr Opin Pediatr,2010,22(4):524-529.
[4] Wang HX,Zhou Y,Tang CX,et al.Association between bisphenol A exposure and body mass index in Chinese school children:a cross-sectional study[J].Environ Health,2012,11:79-88.
[5] Vandenberg LN,Maffini MV,Sonnenschein C,et al.Bisphenol-A and the great divide:a review of controversies in the field of endocrine disruption[J].Endocr Rev,2009,30(1):75-95.
[6] 吴同俊,郑力行,吴强恩,等.酶水解-高效液相色谱法测定人血清中双酚A[J].中国工业医学杂志,2006,19(2):70-73.
[7] Lakind JS,Naiman DQ.Daily intake of bisphenol A and potential sources of exposure:2005-2006 national health and nutrition examination survey[J].J Expo Sci Environ Epidemiol,2011,21(3):272-279.
[8] 王卫平.儿科学[M].北京:高等教育出版社,2008:207-209.
[9] Frederiksen H,Nielsen JK,Morck TA,et al.Urinary excretion of phthalate metabolites,phenols and parabens in rural and urban Danish mother-child pairs[J].Int J Hyg Environ Health,2013,216(6):772-783.
[10] Remer T,Neubert A,Maser-Gluth C.Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research[J].Am J Clin Nutr,2002,75(3):561-569.
[11] He Y,Miao M,Herrinton LJ,et al.Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels[J].Environ Res,2009,109(5):629-633.
[12] Mahalingaiah S,Meeker JD,Pearson KR,et al.Temporal variability and predictors of urinary bisphenol A concentrations in men and women[J].Environ Health Perspect,2008,116(2):173-178.
[13] Mendonca K,Hauser R,Calafat AM,et al.Bisphenol A concentrations in maternal breast milk and infant urine[J].Int Arch Occup Environ Health,2014,87(1):13-20.
[14] Hoepner LA,Whyatt RM,Just AC,et al.Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City,prenatal through age 7 years[J].Environ Res,2013,122:38-44.
[15] Casas L,Fernandez MF,Llop S,et al.Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children[J].Environ Int,2011,37(5):858-866.
[16] Becker K,Goen T,Seiwert M,et al.GerES IV:phthalate metabolites and bisphenol A in urine of German children[J].Int J Hyg Environ Health,2009,212(6):685-692.
[17] Li X,Ying GG,Zhao JL,et al.4-Nonylphenol,bisphenol-A and triclosan levels in human urine of children and students in China,and the effects of drinking these bottled materials on the levels[J].Environ Int,2013,52:81-86.
[18] 中央政府门户网站.质检总局公告:6月起禁止生产聚碳酸酯婴幼儿奶瓶[EB/OL].http://www.gov.cn/gzdt/2011-06/01/content_1874583.htm.
[19] European Food Safety Authority.Bisphenol A[EB/OL].http://www.efsa.europa.eu/en/topics/topic/bisphenol.htm.
[20] Lassen TH,Frederiksen H,Jensen TK,et al.Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot,morning,and 24-h urine samples[J].Environ Res,2013,126:164-170.
[21] Doerge DR,Vanlandingham M,Twaddle NC,et al.Lactational transfer of bisphenol A in Sprague-Dawley rats[J].Toxicol Lett,2010,199(3):372-376.
[22] Chapin RE,Adams J,Boekelheide K,et al.NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A[J].Birth Defects Res B Dev Reprod Toxicol,2008,83(3):157-395.
[23] Calafat AM,Ye X,Wong LY,et al.Exposure of the U.S.population to bisphenol A and 4-tertiary-octylphenol:2003-2004[J].Environ Health Perspect,2008,116(1):39-44.
[24] Kim YH,Kim CS,Park S,et al.Gender differences in the levels of bisphenol A metabolites in urine[J].Biochem Biophys Res Commun,2003,312(2):441-448.