Abstract: Objective To explore the correlation of sleep disturbances and fatigue among children with acute leukemia. Methods The main caregivers of 65 children with acute leukemia were surveyed on the Sleep Disturbance Scale for Children (SDSC) and the Pediatric Quality of Life Inventory TM (PedsQL TM) Multidimensional Fatigue Scale (MFS) (Parent Investigation Questionnaire). Results The total score of SDSC scale was (47.83±10.74) on average.The prevalence of sleep disorders of children with acute leukemia was 6.15%.Sleep-wake transition disorders,sleep breathing disorders,and disorders of arousal were the first three common disorders.The total score of PedsQL TMMFS was (60.41±17.26) on average.The ascending order of the three dimensions' score was general fatigue,sleep fatigue and cognitive fatigue.The total score of sleep disturbances was negatively correlated with that of fatigue (r=-0.51,P<0.001),which meaned that the more serious the sleep disturbance was,the more serious the fatigue was. Conclusions The most common sleep disturbances of children with acute leukemia in hospital are sleep-wake transition disorders,sleep breathing disorders,and disorders of arousal.General fatigue and sleep fatigue are the main manifestations of fatigue.Sleep disturbances and fatigue are negatively correlated with each other.

Key words: acute leukemia, sleep disturbances, fatigue, children

摘要： 目的 探讨急性白血病患儿的睡眠紊乱与疲乏的相关性。方法 采用便利抽样选取65名急性白血病儿童病例,对其主要照顾者进行问卷调查,内容包括儿童睡眠紊乱量表(Sleep Disturbance Scale for Children,SDSC)和PedsQL TMMFS儿童多维疲乏量表。结果 急性白血病患儿的睡眠量表总分为(47.83±10.74)分,睡眠紊乱总发生率为6.15%,各维度中睡眠-觉醒转换障碍和睡眠呼吸障碍和觉醒障碍发生率最高。疲乏总分为(60.41±17.26)分,三个维度得分由低到高依次为一般疲乏、休息疲乏和认知疲乏。患儿的睡眠紊乱与疲乏呈负相关(r=-0.51,P<0.01),即患儿睡眠紊乱越严重,疲乏程度越高。结论 急性白血病患儿治疗期间最常见的睡眠紊乱为睡眠-觉醒转换障碍和睡眠呼吸障碍和觉醒障碍,疲乏主要表现为一般疲乏和休息疲乏。急性白血病患儿的睡眠障碍与疲乏状况呈负相关。

关键词: 急性白血病, 睡眠紊乱, 疲乏, 患儿